ITSN2 and SOS2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid)

		ITSN2	SOS2
Description		intersectin 2	SOS Ras/Rho guanine nucleotide exchange factor 2
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Presynaptic Membrane Extracellular Exosome Intracellular Vesicle	Cytosol Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Endocytosis Endosomal Transport Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension	B Cell Homeostasis Lymphocyte Homeostasis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Regulation Of Pro-B Cell Differentiation
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling RAC1 GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Sjögren's syndrome ( 24097067) Total cholesterol levels ( 33339817)	Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 30054594 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		74 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SNCA SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	20 interacting genes: ABI1 ABL1 BIN1 CD2AP CREBBP CRKL DSCAM EGFR GRAP2 GRB2 HRAS ITSN1 ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9 UBASH3A
Entrez ID		50618	6655
HPRD ID		09193	03149
Ensembl ID		ENSG00000198399	ENSG00000100485
Uniprot IDs		A6H8W8 Q9NZM3	Q07890
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO	6EIE 8T5G 8T5M 8T5R 8UC9 8UF2 8UH0 9BVE 9BVF 9BVI 9GIN
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Endocytosis Cell Projection Vesicle-mediated Transport Actin Filament-based Movement Import Into Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cytoplasm Synaptic Vesicle Endocytosis Organelle Localization Glutamatergic Synapse Presynaptic Endocytosis Actin Binding Vesicle-mediated Transport In Synapse Organelle Organization Supramolecular Fiber Organization Cadherin Binding Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cellular Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Membrane Organization MRNA Binding Protein Complex Oligomerization Regulation Of Vesicle-mediated Transport Regulation Of Angiotensin-activated Signaling Pathway Intracellular Transport Apical Constriction Positive Regulation Of RNA Export From Nucleus Cellular Component Assembly Cytosol Actin Cytoskeleton Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cell-cell Signaling Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cellular Component Organization Plasma Membrane Tubulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Plasma Membrane Intracellular Signal Transduction Response To Growth Factor Cytosol Proline-rich Region Binding Lipid Tube Assembly Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Vesicle Regulation Of Actin Cytoskeleton Organization Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding MAPK Cascade Regulation Of MAPK Cascade Regulation Of Immune Response Ruffle Positive Regulation Of Immune Response Cytoplasm Epidermal Growth Factor Binding Small GTPase-mediated Signal Transduction Synaptic Vesicle Endocytosis Cellular Response To Growth Factor Stimulus Endosome Regulation Of ERK1 And ERK2 Cascade Presynaptic Endocytosis Positive Regulation Of Cellular Component Biogenesis
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