ITSN2 and CHIC2

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN2	CHIC2
Gene Name		intersectin 2	cysteine-rich hydrophobic domain 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Cellular_component Golgi-associated Vesicle Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Molecular_function Protein Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity	Golgi To Plasma Membrane Transport Biological_process
Pathways
Drugs
Diseases
GWAS		Working memory ( 21107309)	Blood pressure ( 21909110)
Protein-Protein Interactions		75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	26 interactors: CATSPER1 CDR2 CEP44 GMCL1 HOXA1 ITSN2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 MDFI MEOX2 NOTCH2NL OTX1 PLEKHF2 PNMA1 SPERT TCF4 TOP3B TUBGCP4 U2AF2
Entrez ID		50618	26511
HPRD ID		09193	10373
Ensembl ID		ENSG00000198399	ENSG00000109220
Uniprot IDs		A6H8W8 Q9NZM3	Q9UKJ5
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Embryonic Organ Morphogenesis Pattern Specification Process Embryonic Organ Development Anterior/posterior Pattern Specification Embryo Development Embryonic Morphogenesis Optokinetic Behavior Abducens Nerve Formation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Facial Nucleus Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Diencephalon Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Inner Ear Morphogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Rhombomere 4 Development Semicircular Canal Formation Developmental Process Rhombomere 3 Development Rhombomere 5 Development Maintenance Of DNA Repeat Elements Positive Regulation Of Metabolic Process Embryonic Skeletal System Morphogenesis Ear Morphogenesis Organ Morphogenesis Metencephalon Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Somite Specification Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Blood Vessel Development Multicellular Organismal Development Regulation Of Transcription From RNA Polymerase II Promoter Vasculature Development Diencephalon Morphogenesis Embryonic Genitalia Morphogenesis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Embryonic Skeletal System Development Myoblast Fate Commitment Hindbrain Development Single Organism Reproductive Process Embryonic Neurocranium Morphogenesis Secretory Granule Localization
Tagcloud ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Difference) ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Intersection) ?