ITSN2 and LTBP4

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN2	LTBP4
Gene Name		intersectin 2	latent transforming growth factor beta binding protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Transforming Growth Factor Beta-activated Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Transforming Growth Factor Beta Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organismal Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Proteolysis Extracellular Matrix Organization Growth Hormone Secretion Regulation Of Cell Differentiation
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Working memory ( 21107309)
Protein-Protein Interactions		75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	11 interactors: ATN1 ATXN7 CACNA1A CRKL CRY1 FBLN1 FRAT1 GFI1B ITSN2 RAC1 TGFB1
Entrez ID		50618	8425
HPRD ID		09193	05274
Ensembl ID		ENSG00000198399	ENSG00000090006
Uniprot IDs		A6H8W8 Q9NZM3	B3KXY6 Q8N2S1
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Endocytosis Multicellular Organismal Development Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Kinase Activity Bone Remodeling Positive Regulation Of Catalytic Activity Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Cellular Process Regulation Of Vesicle-mediated Transport Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Vestibular Nucleus Development Negative Regulation Of Glucocorticoid Secretion Blue Light Signaling Pathway Active Induction Of Host Immune Response By Virus Cell Death Death Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Morphogenesis Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Kinase Activity Negative Regulation Of RNA Biosynthetic Process Tissue Remodeling Engulfment Of Apoptotic Cell Negative Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Response To Blue Light Regulation Of Histone Modification Positive Regulation Of Behavior
Tagcloud ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	15q24 19q13 20q13 21q21 acquire aggressiveness akt2 angptl4 anoikis bsg cadm2 clustered commonality ctc ctcs dissemination distinctiveness dormancy highlighting intravasation mcrs numbl occult originate plausible signature signatures tff3 tgfbeta
Tagcloud (Difference) ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	15q24 19q13 20q13 21q21 acquire aggressiveness akt2 angptl4 anoikis bsg cadm2 clustered commonality ctc ctcs dissemination distinctiveness dormancy highlighting intravasation mcrs numbl occult originate plausible signature signatures tff3 tgfbeta
Tagcloud (Intersection) ?