ITSN2 and RNF20

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN2	RNF20
Gene Name		intersectin 2	ring finger protein 20, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	P53 Binding Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cell Migration Positive Regulation Of Histone Methylation Histone H2B Ubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Working memory ( 21107309)
Protein-Protein Interactions		75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	22 interactors: AMOTL2 ATM CDC73 HIST1H2BB HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HTT ITSN2 MSL1 PA2G4 PAF1 SMURF2 UBC UBE2A UBE2B UBE2E1 USHBP1 WAC ZDHHC17
Entrez ID		50618	56254
HPRD ID		09193	07410
Ensembl ID		ENSG00000198399	ENSG00000155827
Uniprot IDs		A6H8W8 Q9NZM3	Q5VTR2
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Histone Ubiquitination Chromatin Organization Histone Modification Histone H2B Ubiquitination Chromosome Organization Protein Monoubiquitination Chromatin Modification Histone Monoubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Cell Cycle Negative Regulation Of Transcription, DNA-templated Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Chromatin Silencing Protein K48-linked Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Cell Cycle Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process G1 DNA Damage Checkpoint Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Histone H2A Ubiquitination Positive Regulation Of MRNA 3'-end Processing Chromatin Silencing At RDNA
Tagcloud ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	abundance coincide contributions di dot1l drives dynamic e3 employ evolutionarily exhibit garnered h2b h2bub1 h3k4me2 h3k79me2 implicate lysines mitosis mitotic normally overlooked patterning ptm reaches requisite rnai stability virtually
Tagcloud (Difference) ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	abundance coincide contributions di dot1l drives dynamic e3 employ evolutionarily exhibit garnered h2b h2bub1 h3k4me2 h3k79me2 implicate lysines mitosis mitotic normally overlooked patterning ptm reaches requisite rnai stability virtually
Tagcloud (Intersection) ?