RUFY1 and EPHA3

Number of citations of the paper that reports this interaction (PMID 11877430)
14

Data Source:
HPRD (in vitro, two hybrid)

		RUFY1	EPHA3
Gene Name		RUN and FYVE domain containing 1	EPH receptor A3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding Protein Transporter Activity	GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Endocytosis Protein Transport Regulation Of Endocytosis	Cell Adhesion Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Eating disorders ( 22911880)	Orofacial clefts ( 22863734)
Protein-Protein Interactions		17 interactors: AP3B2 AP3D1 AP3M1 AP3S1 BMX DIEXF EPHA3 GIT2 ITSN2 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A TCF3 TXNDC17	20 interactors: ABL1 ADAM10 CDKN2A CRK EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 FYN PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 TP53
Entrez ID		80230	2042
HPRD ID		15282	01555
Ensembl ID		ENSG00000176783	ENSG00000044524
Uniprot IDs		A8K7B1 Q96T51	C9JXA2 P29320 Q6P4R6
PDB IDs		2YQM 2YW8	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4
Enriched GO Terms of Interacting Partners?		Anterograde Synaptic Vesicle Transport Intracellular Protein Transport Anterograde Axon Cargo Transport Synaptic Vesicle Transport Axon Cargo Transport Rab Protein Signal Transduction Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Establishment Of Vesicle Localization Intracellular Transport Vesicle Localization Protein Localization Microtubule-based Transport Establishment Of Organelle Localization Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Signaling Cell Communication Organelle Localization Cellular Localization Ras Protein Signal Transduction Post-Golgi Vesicle-mediated Transport Synaptic Transmission Microtubule-based Movement Cytoplasmic Transport Cell-cell Signaling Endosomal Transport Regulation Of Ras GTPase Activity Transport Phagolysosome Assembly Involved In Apoptotic Cell Clearance Small GTPase Mediated Signal Transduction Golgi Vesicle Transport Regulation Of Ras Protein Signal Transduction Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Membrane Organization Cellular Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Process Regulation Of GTPase Activity Canonical Wnt Signaling Pathway Receptor Internalization Involved In Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Regulation Of Endosome Size Response To Stimulus Membrane Organization Eye Pigment Biosynthetic Process Movement Of Cell Or Subcellular Component	Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Differentiation Neuron Projection Development Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Cell Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Cell Projection Organization Locomotion Nervous System Development Response To External Stimulus Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Cell Differentiation Signal Transduction Developmental Process Regulation Of Cell Adhesion Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Phosphorylation Multicellular Organismal Development Regulation Of Cell-cell Adhesion Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation
Tagcloud ?			arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Difference) ?			arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Intersection) ?