ITSN2 and AMPH

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN2	AMPH
Gene Name		intersectin 2	amphiphysin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Synaptic Vesicle Actin Cytoskeleton Cell Junction Synaptic Vesicle Membrane Leading Edge Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Protein Binding Phospholipid Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity	Endocytosis Synaptic Transmission Learning Synaptic Vesicle Endocytosis
Pathways
Drugs
Diseases
GWAS		Working memory ( 21107309)
Protein-Protein Interactions		75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	27 interactors: AP1B1 AP2A1 AP2A2 ARL16 BIN1 CABIN1 CCDC67 CDK1 CDK5 CDK5R1 CLTC DNM1 DNM2 DYRK1A ITSN2 KHDRBS1 MAPK6 NECAP1 PLD2 PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN
Entrez ID		50618	273
HPRD ID		09193	02687
Ensembl ID		ENSG00000198399	ENSG00000078053
Uniprot IDs		A6H8W8 Q9NZM3	P49418
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY	1KY7 1UTC 3SOG 4ATM
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Endocytosis Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Receptor Metabolic Process Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Recycling Receptor-mediated Endocytosis Synaptic Vesicle Transport Receptor Internalization Regulation Of Signaling Synaptic Transmission Axon Guidance Peptidyl-threonine Phosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Neuron Projection Development Axon Development Regulation Of Signal Transduction Cell Projection Morphogenesis Establishment Of Vesicle Localization Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Positive Regulation Of Programmed Cell Death Cell Part Morphogenesis Chemotaxis Vesicle Localization Regulation Of Cellular Component Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Localization Positive Regulation Of Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Cycle Arrest Neurotrophin Signaling Pathway Establishment Of Localization In Cell
Tagcloud ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	10a 10as 6b 6br 7h amphetamine antipsychotic butan cataleptogenic demonstrable dimethoxy headtwitch hexahydro histaminergic ht2a ht2c hydrochloride hyperlocomotion id50 iodoamphetamine mesocortical mesolimbic microdialysis neurotransmission pyrido pyrrolo quinoxalin sert unwanted
Tagcloud (Difference) ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	10a 10as 6b 6br 7h amphetamine antipsychotic butan cataleptogenic demonstrable dimethoxy headtwitch hexahydro histaminergic ht2a ht2c hydrochloride hyperlocomotion id50 iodoamphetamine mesocortical mesolimbic microdialysis neurotransmission pyrido pyrrolo quinoxalin sert unwanted
Tagcloud (Intersection) ?