RUFY1 and TXNDC17

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RUFY1	TXNDC17
Description		RUN and FYVE domain containing 1	thioredoxin domain containing 17
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding	Peroxidase Activity Protein Binding Protein-disulfide Reductase [NAD(P)H] Activity
	Biological Process	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Oxidant Detoxification
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25	9 interacting genes: AVP DYNLL1 EXOSC8 INCA1 INS OXT RUFY1 TINF2 TXNRD1
Entrez ID		80230	84817
HPRD ID		15282	11656
Ensembl ID		ENSG00000176783	ENSG00000129235
Uniprot IDs		A8K7B1 Q96T51	A0A140VJY7 Q9BRA2
PDB IDs		2YQM 2YW8	1WOU
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement	Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Grooming Behavior Positive Regulation Of Secretion Hormone Activity Positive Regulation Of Secretion By Cell Maternal Behavior Parental Behavior Secretory Granule Mating Behavior Neuronal Dense Core Vesicle Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Reproductive Behavior Identical Protein Binding Response To Electrical Stimulus Regulation Of Secretion By Cell Regulation Of Secretion Social Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding NADPH Peroxidase Activity Positive Regulation Of Transport Regulation Of Amine Transport V1A Vasopressin Receptor Binding Regulation Of Transport Negative Regulation Of Glycogen Catabolic Process Regulation Of Hindgut Contraction Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Perinucleolar Chromocenter Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Penile Erection Positive Regulation Of Norepinephrine Secretion Positive Regulation Of Female Receptivity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Cell Growth Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance
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