ITSN2 and NBR1

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN2	NBR1
Gene Name		intersectin 2	neighbor of BRCA1 gene 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Pre-autophagosomal Structure Lysosome Late Endosome Autophagic Vacuole Cytosol Membrane Cytoplasmic Vesicle M Band Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation Protein Oligomerization
Pathways
Drugs
Diseases
GWAS		Working memory ( 21107309)
Protein-Protein Interactions		75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	14 interactors: ATXN1L CALM1 CIB1 FEZ1 GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A SQSTM1 SYT4 TTN USP8 VTA1
Entrez ID		50618	4077
HPRD ID		09193	01326
Ensembl ID		ENSG00000198399	ENSG00000188554
Uniprot IDs		A6H8W8 Q9NZM3	Q14596
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY	1WJ6 2BKF 2CP8 2G4S 2L8J
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway	Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Type B Pancreatic Cell Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Hypermethylation Of CpG Island Cellular Response To Interleukin-3 Regulation Of Cellular Protein Metabolic Process Macroautophagy Establishment Of Localization In Cell Glycogen Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Polysaccharide Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Cellular Localization Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Response To External Stimulus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Negative Regulation Of Transport Energy Reserve Metabolic Process Regulation Of DNA Methylation Cellular Response To Starvation Nucleophagy Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Autophagy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Gene Expression By Genetic Imprinting Mitochondrion Degradation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress
Tagcloud ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation
Tagcloud (Difference) ?		abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates	abrogates autophagy bnip3l carried connections endoplasmic er extent hct116 interest ire1 microarray nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation
Tagcloud (Intersection) ?