MAP4K2 and POT1

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		MAP4K2	POT1
Description		mitogen-activated protein kinase kinase kinase kinase 2	protection of telomeres 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Shelterin Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity	DNA Binding Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding
	Biological Process	Immune System Process Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Positive Regulation Of Telomeric D-loop Disassembly Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Fostamatinib
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)	Chronic lymphocytic leukemia ( 24292274 28165464) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 31171785 32109421) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Telomere length ( 33941849)
Interacting Genes		19 interacting genes: DEFB1 GABARAP GABARAPL1 GABARAPL2 HNRNPA2B1 LATS1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNCA SNRNP35 STRN4 TRAF2 XRCC6	166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		5871	25913
HPRD ID		04408	07572
Ensembl ID		ENSG00000168067	ENSG00000128513
Uniprot IDs		Q12851	A8MTK3 Q5MJ33 Q9NUX5
PDB IDs			1XJV 3KJO 3KJP 5H65 5UN7 7QXB 7QXS 7S1O 7S1T 7S1U 8SH0 8SH1 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Beta-tubulin Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding GABA Receptor Binding Phospholipid Binding Single-stranded Telomeric DNA Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly Autophagosome Maturation Autophagosome Membrane Mitophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Protein Modification Process Positive Regulation Of JUN Kinase Activity Autophagy Of Mitochondrion Autophagosome Regulation Of Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Metabolic Process Autophagosome Assembly Regulation Of Kinase Activity Cellular Response To Stress Autophagosome Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Autophagy Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Kinase Activity Telomeric DNA Binding Positive Regulation Of Kinase Activity Chromosome Organization Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Binding Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Protein Phosphorylation Chromosome, Telomeric Region Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Cytoplasm Cytosol Extracellular Exosome Cytoskeleton Organization Actin Filament Organization Cytoskeleton Protein Binding Cadherin Binding Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Supramolecular Fiber Organization Cellular Response To Heat Actin Binding Carbohydrate Catabolic Process Response To Heat Pyruvate Metabolic Process Organelle Organization Glycolytic Process Nucleoside Phosphate Metabolic Process ADP Catabolic Process Vesicle Purine Nucleotide Metabolic Process Identical Protein Binding Generation Of Precursor Metabolites And Energy Purine Ribonucleoside Diphosphate Catabolic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Response To Temperature Stimulus Nucleoside Diphosphate Catabolic Process Purine Nucleotide Catabolic Process Ficolin-1-rich Granule Lumen Glucose Metabolic Process Microtubule Cytoskeleton Organization Nucleoside Phosphate Catabolic Process Actin Filament-based Process Actin Cytoskeleton Organization Monocarboxylic Acid Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Cellular Component Organization Cytoskeletal Protein Binding Protein Sequestering Activity Focal Adhesion Catabolic Process Monosaccharide Metabolic Process Actin Monomer Binding Cellular Response To Raffinose Nucleotide Catabolic Process Organic Acid Metabolic Process
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