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MAP4K2
Gene Name
mitogen-activated protein kinase kinase kinase kinase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Basolateral Plasma Membrane
Molecular Function
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Small GTPase Regulator Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
Protein Phosphorylation
Vesicle Targeting
Immune Response
JNK Cascade
Activation Of JUN Kinase Activity
Intracellular Signal Transduction
Innate Immune Response
Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS
Urate levels (
21768215
)
Protein-protein Interactions
13 interactors:
DEFB1
HNRNPA2B1
MAP2K4
MAP3K11
MCM3AP-AS1
NACAD
POT1
PRDX4
RAB8A
SERPINA4
SNRNP35
TRAF2
XRCC6
Entrez ID
5871
HPRD ID
04408
Ensembl ID
ENSG00000168067
Uniprot IDs
Q12851
Q86VU3
PDB IDs
Enriched GO Terms of Interacting Partners
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Positive Regulation Of JUN Kinase Activity
Regulation Of JUN Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transferase Activity
Positive Regulation Of MAP Kinase Activity
Activation Of JUN Kinase Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Neuron Death
Regulation Of MAP Kinase Activity
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Innate Immune Response
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of DNA Replication
Telomere Maintenance
Positive Regulation Of DNA Strand Elongation
Negative Regulation Of Male Germ Cell Proliferation
Positive Regulation Of Neuron Death
DNA Duplex Unwinding
DNA Geometric Change
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Positive Regulation Of MAPK Cascade
Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Cellular Hyperosmotic Salinity Response
Regulation Of Male Germ Cell Proliferation
Golgi Vesicle Fusion To Target Membrane
Telomere Formation Via Telomerase
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Regulation Of DNA Replication
Cellular Response To Sorbitol
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Cellular Response To X-ray
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