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MAP4K2 and MAP2K4
Number of citations of the paper that reports this interaction (PMID
9712898
)
39
Data Source:
BioGRID
(pull down)
MAP4K2
MAP2K4
Gene Name
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Basolateral Plasma Membrane
Intracellular
Nucleus
Cytosol
Axon
Dendrite Cytoplasm
Perikaryon
Molecular Function
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Small GTPase Regulator Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
Protein Phosphorylation
Vesicle Targeting
Immune Response
JNK Cascade
Activation Of JUN Kinase Activity
Intracellular Signal Transduction
Innate Immune Response
Positive Regulation Of JNK Cascade
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Signal Transduction
JNK Cascade
Activation Of JUN Kinase Activity
Pathogenesis
Peptidyl-tyrosine Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Innate Immune Response
Positive Regulation Of DNA Replication
Stress-activated MAPK Cascade
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Mechanical Stimulus
Cellular Response To Sorbitol
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Uptake and actions of bacterial toxins
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Uptake and function of anthrax toxins
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
Drugs
Diseases
GWAS
Urate levels (
21768215
)
Response to amphetamines (
22952603
)
Protein-Protein Interactions
13 interactors:
DEFB1
HNRNPA2B1
MAP2K4
MAP3K11
MCM3AP-AS1
NACAD
POT1
PRDX4
RAB8A
SERPINA4
SNRNP35
TRAF2
XRCC6
37 interactors:
AKT1
APP
ARRB1
ARRB2
CFLAR
DUSP22
EFNA4
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
RBBP8
SPAG9
TRIB1
ZAK
Entrez ID
5871
6416
HPRD ID
04408
03213
Ensembl ID
ENSG00000168067
ENSG00000065559
Uniprot IDs
Q12851
Q86VU3
B7ZA62
P45985
PDB IDs
3ALN
3ALO
3VUT
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of JUN Kinase Activity
Regulation Of JUN Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transferase Activity
Positive Regulation Of MAP Kinase Activity
Activation Of JUN Kinase Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Neuron Death
Regulation Of MAP Kinase Activity
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Innate Immune Response
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of DNA Replication
Telomere Maintenance
Positive Regulation Of DNA Strand Elongation
Negative Regulation Of Male Germ Cell Proliferation
Positive Regulation Of Neuron Death
DNA Duplex Unwinding
DNA Geometric Change
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Positive Regulation Of MAPK Cascade
Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Cellular Hyperosmotic Salinity Response
Regulation Of Male Germ Cell Proliferation
Golgi Vesicle Fusion To Target Membrane
Telomere Formation Via Telomerase
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Regulation Of DNA Replication
Cellular Response To Sorbitol
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Cellular Response To X-ray
MAPK Cascade
Signal Transduction By Phosphorylation
Regulation Of MAPK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of MAPK Cascade
Activation Of MAPK Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Activation Of Protein Kinase Activity
Regulation Of MAP Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
JNK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
Activation Of MAPKK Activity
Positive Regulation Of Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Kinase Activity
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Regulation Of Signal Transduction
Phosphorylation
Regulation Of Signaling
Regulation Of JNK Cascade
Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Phosphate-containing Compound Metabolic Process
Positive Regulation Of JUN Kinase Activity
Cell Death
Death
Positive Regulation Of JNK Cascade
Regulation Of JUN Kinase Activity
Tagcloud
?
aurka
aurkb
bioinformatics
cdkn2a
copy
custom
describing
epha5
flt4
frameshift
insertions
interrogating
kdm6a
leiomyosarcomas
locally
losses
multiplexed
nf1
ngs
notch1
pdgfrb
pik3ca
pipeline
rationale
rb1
sarcomas
soft
stratification
targetable
Tagcloud (Difference)
?
aurka
aurkb
bioinformatics
cdkn2a
copy
custom
describing
epha5
flt4
frameshift
insertions
interrogating
kdm6a
leiomyosarcomas
locally
losses
multiplexed
nf1
ngs
notch1
pdgfrb
pik3ca
pipeline
rationale
rb1
sarcomas
soft
stratification
targetable
Tagcloud (Intersection)
?