MAP4K2 and SERPINA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP4K2	SERPINA4
Description		mitogen-activated protein kinase kinase kinase kinase 2	serpin family A member 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Immune System Process Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade
Pathways			Platelet degranulation Developmental Lineage of Pancreatic Acinar Cells
Drugs		Fostamatinib	Zinc Copper Zinc acetate
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)	Blood protein levels ( 30072576) Vaspin levels ( 22907691)
Interacting Genes		19 interacting genes: DEFB1 GABARAP GABARAPL1 GABARAPL2 HNRNPA2B1 LATS1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNCA SNRNP35 STRN4 TRAF2 XRCC6	14 interacting genes: CFTR CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		5871	5267
HPRD ID		04408	01004
Ensembl ID		ENSG00000168067	ENSG00000100665
Uniprot IDs		Q12851	A0A024R6I9 P29622
PDB IDs			6F02
Enriched GO Terms of Interacting Partners?		Beta-tubulin Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding GABA Receptor Binding Phospholipid Binding Single-stranded Telomeric DNA Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly Autophagosome Maturation Autophagosome Membrane Mitophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Protein Modification Process Positive Regulation Of JUN Kinase Activity Autophagy Of Mitochondrion Autophagosome Regulation Of Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Metabolic Process Autophagosome Assembly Regulation Of Kinase Activity Cellular Response To Stress Autophagosome Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Autophagy Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Kinase Activity Telomeric DNA Binding Positive Regulation Of Kinase Activity Chromosome Organization Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Binding Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Protein Phosphorylation Chromosome, Telomeric Region Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
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