MAP4K2 and SERPINA4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP4K2	SERPINA4
Gene Name		mitogen-activated protein kinase kinase kinase kinase 2	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Basolateral Plasma Membrane	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade	Negative Regulation Of Endopeptidase Activity
Pathways
Drugs
Diseases
GWAS		Urate levels ( 21768215)	Vaspin levels ( 22907691)
Protein-Protein Interactions		13 interactors: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6	13 interactors: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1D1
Entrez ID		5871	5267
HPRD ID		04408	01004
Ensembl ID		ENSG00000168067	ENSG00000100665
Uniprot IDs		Q12851 Q86VU3	P29622
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Activation Of JUN Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Positive Regulation Of DNA Replication Telomere Maintenance Positive Regulation Of DNA Strand Elongation Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Neuron Death DNA Duplex Unwinding DNA Geometric Change Toll-like Receptor 4 Signaling Pathway JNK Cascade Positive Regulation Of MAPK Cascade Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Hyperosmotic Salinity Response Regulation Of Male Germ Cell Proliferation Golgi Vesicle Fusion To Target Membrane Telomere Formation Via Telomerase Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Regulation Of DNA Replication Cellular Response To Sorbitol Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To X-ray	Activation Of MAPKKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process JNK Cascade Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Regulation Of Cell-matrix Adhesion Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Locomotion Positive Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of JNK Cascade Regulation Of Cell Adhesion Defense Response
Tagcloud ?			academic bcl2 beadchip caucasian cohorts complicates diego discovery entirely genotyped genotyping hundred illumina injury kallistatin kidney nucleotide polymorphisms predicts rs12457893 rs8094315 san septic shock sixty split tertiary thousand validation
Tagcloud (Difference) ?			academic bcl2 beadchip caucasian cohorts complicates diego discovery entirely genotyped genotyping hundred illumina injury kallistatin kidney nucleotide polymorphisms predicts rs12457893 rs8094315 san septic shock sixty split tertiary thousand validation
Tagcloud (Intersection) ?