MAP4K2 and HNRNPA2B1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP4K2	HNRNPA2B1
Gene Name		mitogen-activated protein kinase kinase kinase kinase 2	heterogeneous nuclear ribonucleoprotein A2/B1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Basolateral Plasma Membrane	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Membrane Ribonucleoprotein Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Nucleotide Binding RNA Binding Protein Binding Single-stranded Telomeric DNA Binding Poly(A) RNA Binding Pre-mRNA Intronic Binding
	Biological Process	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Transport
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		13 interactors: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6	17 interactors: CDKN2A CSNK2A1 CSNK2B ERG HIPK3 HIST3H3 HNRNPL LIG4 MAP4K2 NR4A1 PSMA3 SNRNP70 SREK1 TTF2 VHL YAE1D1 ZMYM2
Entrez ID		5871	3181
HPRD ID		04408	02526
Ensembl ID		ENSG00000168067	ENSG00000122566
Uniprot IDs		Q12851 Q86VU3	P22626
PDB IDs			1X4B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Activation Of JUN Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Positive Regulation Of DNA Replication Telomere Maintenance Positive Regulation Of DNA Strand Elongation Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Neuron Death DNA Duplex Unwinding DNA Geometric Change Toll-like Receptor 4 Signaling Pathway JNK Cascade Positive Regulation Of MAPK Cascade Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Hyperosmotic Salinity Response Regulation Of Male Germ Cell Proliferation Golgi Vesicle Fusion To Target Membrane Telomere Formation Via Telomerase Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Regulation Of DNA Replication Cellular Response To Sorbitol Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To X-ray	Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Cell Death Cell Death Death RNA Splicing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process MRNA Processing Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity MRNA Metabolic Process Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition RNA Processing Regulation Of Catalytic Activity Cellular Protein Modification Process RNA Biosynthetic Process DNA Ligation Involved In DNA Recombination Negative Regulation Of Potassium Ion Export Regulation Of Proteolysis Regulation Of RNA Metabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Phosphorylation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cellular Macromolecule Biosynthetic Process
Tagcloud ?			amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution taf15 tardbp tdp43 tremor
Tagcloud (Difference) ?			amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution taf15 tardbp tdp43 tremor
Tagcloud (Intersection) ?