MAP4K2 and SNRNP35

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP4K2	SNRNP35
Gene Name		mitogen-activated protein kinase kinase kinase kinase 2	small nuclear ribonucleoprotein 35kDa (U11/U12)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Basolateral Plasma Membrane	Nucleus U12-type Spliceosomal Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Nucleotide Binding RNA Binding
	Biological Process	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade	MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		13 interactors: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6	6 interactors: APP ILK MAP4K2 SRPK2 TAB1 TNFSF11
Entrez ID		5871	11066
HPRD ID		04408	15595
Ensembl ID		ENSG00000168067
Uniprot IDs		Q12851 Q86VU3	Q16560
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Activation Of JUN Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Positive Regulation Of DNA Replication Telomere Maintenance Positive Regulation Of DNA Strand Elongation Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Neuron Death DNA Duplex Unwinding DNA Geometric Change Toll-like Receptor 4 Signaling Pathway JNK Cascade Positive Regulation Of MAPK Cascade Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Hyperosmotic Salinity Response Regulation Of Male Germ Cell Proliferation Golgi Vesicle Fusion To Target Membrane Telomere Formation Via Telomerase Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Regulation Of DNA Replication Cellular Response To Sorbitol Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To X-ray	Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity JNK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Immune Response Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Activation Of MAPK Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation MAPK Cascade Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Immune System Process Regulation Of Protein Metabolic Process Activation Of JUN Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Protein Phosphorylation Positive Regulation Of JUN Kinase Activity Defense Response Positive Regulation Of Protein Kinase B Signaling Regulation Of JUN Kinase Activity
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