MAP4K2 and NACAD

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP4K2	NACAD
Description		mitogen-activated protein kinase kinase kinase kinase 2	NAC alpha domain containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane	Nucleus Cytoplasm Nascent Polypeptide-associated Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity	Protein Binding Unfolded Protein Binding
	Biological Process	Immune System Process Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade	Protein Targeting To Membrane Protein Transport
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)	Eosinophil count ( 32888494)
Interacting Genes		19 interacting genes: DEFB1 GABARAP GABARAPL1 GABARAPL2 HNRNPA2B1 LATS1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNCA SNRNP35 STRN4 TRAF2 XRCC6	10 interacting genes: AGTR1 CBLC HDAC6 MAP4K2 NR4A1 PTK2 RPS27 STAT3 TNNT1 YAE1
Entrez ID		5871	23148
HPRD ID		04408
Ensembl ID		ENSG00000168067	ENSG00000136274
Uniprot IDs		Q12851	O15069
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta-tubulin Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding GABA Receptor Binding Phospholipid Binding Single-stranded Telomeric DNA Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly Autophagosome Maturation Autophagosome Membrane Mitophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Protein Modification Process Positive Regulation Of JUN Kinase Activity Autophagy Of Mitochondrion Autophagosome Regulation Of Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Metabolic Process Autophagosome Assembly Regulation Of Kinase Activity Cellular Response To Stress Autophagosome Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Autophagy Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Kinase Activity Telomeric DNA Binding Positive Regulation Of Kinase Activity Chromosome Organization Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Binding Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Protein Phosphorylation Chromosome, Telomeric Region Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Epithelial Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Endothelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Protein-containing Complex Organization Bradykinin Receptor Binding Positive Regulation Of Cell Differentiation Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Nuclear Receptor Activity Cellular Response To Hormone Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Epithelial Cell Migration ERBB Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Phosphorylation Protein Phosphatase Binding Regulation Of Cell Population Proliferation Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Tubulin Deacetylation Positive Regulation Of Response To Oxidative Stress Regulation Of Cholangiocyte Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Angiotensin Type II Receptor Activity
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