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MAP4K2 and NACAD
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
MAP4K2
NACAD
Gene Name
mitogen-activated protein kinase kinase kinase kinase 2
NAC alpha domain containing
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Basolateral Plasma Membrane
Nucleus
Cytoplasm
Molecular Function
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Small GTPase Regulator Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
Protein Phosphorylation
Vesicle Targeting
Immune Response
JNK Cascade
Activation Of JUN Kinase Activity
Intracellular Signal Transduction
Innate Immune Response
Positive Regulation Of JNK Cascade
Protein Transport
Pathways
Drugs
Diseases
GWAS
Urate levels (
21768215
)
Protein-Protein Interactions
13 interactors:
DEFB1
HNRNPA2B1
MAP2K4
MAP3K11
MCM3AP-AS1
NACAD
POT1
PRDX4
RAB8A
SERPINA4
SNRNP35
TRAF2
XRCC6
8 interactors:
CBLC
HDAC6
MAP4K2
NR4A1
PTK2
RPS27
TNNT1
YAE1D1
Entrez ID
5871
23148
HPRD ID
04408
Ensembl ID
ENSG00000168067
ENSG00000136274
Uniprot IDs
Q12851
Q86VU3
O15069
PDB IDs
Enriched GO Terms of Interacting Partners
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Positive Regulation Of JUN Kinase Activity
Regulation Of JUN Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transferase Activity
Positive Regulation Of MAP Kinase Activity
Activation Of JUN Kinase Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Neuron Death
Regulation Of MAP Kinase Activity
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Innate Immune Response
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of DNA Replication
Telomere Maintenance
Positive Regulation Of DNA Strand Elongation
Negative Regulation Of Male Germ Cell Proliferation
Positive Regulation Of Neuron Death
DNA Duplex Unwinding
DNA Geometric Change
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Positive Regulation Of MAPK Cascade
Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Cellular Hyperosmotic Salinity Response
Regulation Of Male Germ Cell Proliferation
Golgi Vesicle Fusion To Target Membrane
Telomere Formation Via Telomerase
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Regulation Of DNA Replication
Cellular Response To Sorbitol
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Cellular Response To X-ray
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Organelle Localization
Endothelial Cell Migration
Regulation Of Catalytic Activity
Epithelial Cell Migration
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Hsp90 Deacetylation
Epithelium Migration
Regulation Of Receptor Activity
Response To Growth Factor
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Polyubiquitinated Misfolded Protein Transport
Regulation Of Proteolysis
Regulation Of Epithelial Cell Migration
Regulation Of Protein Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Ameboidal-type Cell Migration
Netrin-activated Signaling Pathway
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of Kinase Activity
Innate Immune Response
Negative Regulation Of Cellular Protein Metabolic Process
Establishment Of Localization In Cell
Cellular Macromolecule Catabolic Process
Protein Complex Disassembly
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Synapse Assembly
Slow-twitch Skeletal Muscle Fiber Contraction
Aggresome Assembly
Tubulin Deacetylation
Positive Regulation Of Oxidative Stress-induced Cell Death
Peptidyl-lysine Deacetylation
Signal Complex Assembly
Fc Receptor Signaling Pathway
Cellular Response To Misfolded Protein
Regulation Of Protein Phosphorylation
Cellular Localization
Positive Regulation Of Receptor Biosynthetic Process
Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of MAP Kinase Activity
Cellular Protein Metabolic Process
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Response To Misfolded Protein
Establishment Of Organelle Localization
Positive Regulation Of Cellular Metabolic Process
Angiogenesis
Positive Regulation Of Cell Migration
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