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PKN1 and UBR2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PKN1
UBR2
Description
protein kinase N1
ubiquitin protein ligase E3 component n-recognin 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Membrane
Midbody
Cytoplasmic Vesicle
Cleavage Furrow
Protein-containing Complex
Ubiquitin Ligase Complex
Chromatin
Nucleus
Chromosome
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Histone H3T11 Kinase Activity
Histone Binding
Histone Deacetylase Binding
Nuclear Androgen Receptor Binding
Protein Serine Kinase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
L-leucine Binding
Histone H2A Ubiquitin Ligase Activity
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Hyperosmotic Response
Signal Transduction
Epithelial Cell Migration
Negative Regulation Of B Cell Proliferation
Intracellular Signal Transduction
Post-translational Protein Modification
Positive Regulation Of DNA-templated Transcription
Spleen Development
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Cell Motility
Ubiquitin-dependent Protein Catabolic Process
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Male Meiosis I
Spermatogenesis
Transposable Element Silencing
Protein Ubiquitination
Protein Catabolic Process
Heterochromatin Formation
Negative Regulation Of TOR Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Protein K63-linked Ubiquitination
Cellular Response To L-leucine
Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RAC1 GTPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
HDL cholesterol levels in HIV infection (
33109212
)
Lung cancer in never smokers (
28604730
)
Obesity-related traits (
23251661
)
Serum total protein levels (
29403010
)
Interacting Genes
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DNAAF19
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
RHOB
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
11 interacting genes:
ATF3
CRYAA
H2AC20
H2BC8
NTAN1
NTAQ1
PKN1
SUOX
UBE2B
UBE2D2
UBE2H
Entrez ID
5585
23304
HPRD ID
03019
09853
Ensembl ID
ENSG00000123143
ENSG00000024048
Uniprot IDs
Q16512
B3KXG6
Q8IWV8
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
3NY2
3NY3
5TDA
5TDB
5TDD
5UM3
Enriched GO Terms of Interacting Partners
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Cytoskeleton
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Intermediate Filament
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Organelle Organization
Keratin Filament
Morphogenesis Of An Epithelium
Structural Constituent Of Cytoskeleton
Cytosol
Identical Protein Binding
Structural Molecule Activity
Protein Binding
Tissue Morphogenesis
Microtubule Binding
Regulation Of Microtubule-based Process
Microtubule
Cytoplasm
Regulation Of Microtubule Cytoskeleton Organization
Centrosome
Epithelial Cell Differentiation
Developmental Process
Microtubule Cytoskeleton Organization
Epidermis Development
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Postsynaptic Intermediate Filament Cytoskeleton Organization
Neurofilament Bundle Assembly
Protein Localization To Cytoskeleton
Intermediate Filament Cytoskeleton
Cellular Component Assembly
Microtubule-based Process
Postsynaptic Intermediate Filament Cytoskeleton
Tumor Necrosis Factor Receptor Superfamily Complex
Cellular Developmental Process
Axon Development
Neurofibrillary Tangle
Regulation Of Synapse Maturation
Tumor Necrosis Factor Binding
Gamma-tubulin Binding
Intermediate Filament Bundle Assembly
Cell Projection Organization
Regulation Of Organelle Transport Along Microtubule
Response To Electrical Stimulus
Regulation Of Canonical NF-kappaB Signal Transduction
Neurofilament Cytoskeleton Organization
Thioesterase Binding
Focal Adhesion
Protein-N-terminal Asparagine Amidohydrolase Activity
Ubiquitin Conjugating Enzyme Activity
Protein K48-linked Ubiquitination
Nucleus
Modification-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Sulfite Oxidase Activity
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein-N-terminal Glutamine Amidohydrolase Activity
Protein Autoubiquitination
CHOP-ATF3 Complex
Protein Heterodimerization Activity
Post-translational Protein Modification
Chromatin Organization
Positive Regulation Of Reciprocal Meiotic Recombination
Structural Constituent Of Chromatin
Histone H3T11 Kinase Activity
Molybdenum Ion Binding
Protein Modification Process
Nucleosome
Molybdopterin Cofactor Binding
Macromolecule Catabolic Process
HULC Complex
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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