PKN1 and ZNF282

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PKN1	ZNF282
Description		protein kinase N1	zinc finger protein 282
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex	Nucleus
	Molecular Function	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Generic Transcription Pathway
Drugs		Fostamatinib
Diseases
GWAS		Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)	Eosinophil count ( 32888494) Hip circumference ( 28552196)
Interacting Genes		83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1	3 interacting genes: MAPKAPK5 PIK3CG PKN1
Entrez ID		5585	8427
HPRD ID		03019	04549
Ensembl ID		ENSG00000123143	ENSG00000170265
Uniprot IDs		Q16512	A0A090N8Y3 Q86YG2 Q9UDV7
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Phosphate-containing Compound Metabolic Process Natural Killer Cell Chemotaxis Negative Regulation Of Cardiac Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class IB Negative Regulation Of Striated Muscle Contraction Respiratory Burst Involved In Defense Response Phosphatidylinositol 3-kinase Complex Negative Regulation Of Triglyceride Catabolic Process 1-phosphatidylinositol-4-phosphate 3-kinase Activity Regulation Of Intracellular Signal Transduction Transferase Activity Intracellular Signal Transduction Negative Regulation Of Fibroblast Apoptotic Process Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Neutrophil Extravasation Regulation Of Germinal Center Formation Phosphorylation Protein Phosphorylation Histone H3T11 Kinase Activity Stress-induced Premature Senescence Septin Cytoskeleton Calcium-dependent Protein Serine/threonine Kinase Activity 1-phosphatidylinositol-3-kinase Activity B Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Hepatocyte Apoptotic Process Regulation Of Fibroblast Apoptotic Process Secretory Granule Localization Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Dendritic Cell Chemotaxis T Cell Chemotaxis Negative Regulation Of Muscle Contraction Respiratory Burst Negative Regulation Of Triglyceride Metabolic Process Negative Regulation Of Heart Contraction Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Cellular Extravasation Regulation Of Developmental Process Negative Regulation Of B Cell Proliferation Diacylglycerol-dependent Serine/threonine Kinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?