PKN1 and WBSCR22

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PKN1	WBSCR22
Gene Name		protein kinase N1	Williams Beuren syndrome chromosome region 22
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow	Cellular_component Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	Methyltransferase Activity Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility	Transcription, DNA-templated Regulation Of Transcription, DNA-templated RRNA Processing Biological_process Chromatin Modification Methylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282	3 interactors: OAS1 PKN1 VCP
Entrez ID		5585	114049
HPRD ID		03019	15659
Ensembl ID		ENSG00000123143	ENSG00000071462
Uniprot IDs		Q16512	C9K060 O43709
PDB IDs		1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Ribonuclease Activity Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Deubiquitination Protein Hexamerization Histone H3-T11 Phosphorylation Protein Oligomerization Regulation Of Catalytic Activity Cellular Response To Interferon-alpha Aggresome Assembly Translesion Synthesis Response To Interferon-alpha Postreplication Repair Hyperosmotic Response Response To Stress Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification ER-associated Ubiquitin-dependent Protein Catabolic Process Activation Of JUN Kinase Activity Histone Phosphorylation Protein Complex Assembly Carbohydrate Metabolic Process Negative Regulation Of Viral Genome Replication Peptidyl-threonine Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Viral Genome Replication Positive Regulation Of JUN Kinase Activity Negative Regulation Of Viral Process Cellular Nitrogen Compound Metabolic Process Regulation Of JUN Kinase Activity JNK Cascade Signal Transduction Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Osmotic Stress Endoplasmic Reticulum Unfolded Protein Response Activation Of Cysteine-type Endopeptidase Activity Cellular Response To Stress Positive Regulation Of Catalytic Activity ER To Golgi Vesicle-mediated Transport Cellular Response To Unfolded Protein
Tagcloud ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	a549 adm antitumor attenuates camptothecin cddp cddpr chemosensitivity doxorubicin ethyl fluorouracil fu h1299 h460 h460nc harboring hydroxycamptothecin knockdown marginally merm1 metabolite mitomycin mmc nc paclitaxel ptx shrna sn xenograft
Tagcloud (Difference) ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	a549 adm antitumor attenuates camptothecin cddp cddpr chemosensitivity doxorubicin ethyl fluorouracil fu h1299 h460 h460nc harboring hydroxycamptothecin knockdown marginally merm1 metabolite mitomycin mmc nc paclitaxel ptx shrna sn xenograft
Tagcloud (Intersection) ?