PKN1 and MIPOL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PKN1	MIPOL1
Description		protein kinase N1	mirror-image polydactyly 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex	Nucleus
	Molecular Function	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)	Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Longitudinal alcohol consumption ( 26081443) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Red blood cell count ( 32888494) Tonsillectomy ( 27182965 28928442)
Interacting Genes		83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1	75 interacting genes: AIRIM ANKRD23 ARNT2 ATP5PO BEX2 BYSL C1orf35 CATSPERT CCDC120 CCDC146 CCDC33 CCT3 CDC37 CDK18 CKS1B DAXX DGCR6 DSCR9 EAF1 EIF4E2 ENKD1 EXOC8 FAM124B FAM161A FAM161B FAM90A1 FBF1 FMNL2 GADD45GIP1 GEM HAUS1 KDF1 KIF9 LAGE3 LENG1 MAGEA6 MBD3 MCM7 MFAP1 MOS MYLIP NEBL NTAQ1 PAX6 PBX4 PKN1 PPP1R13B PRDM16 PRPF31 RBM41 RCOR3 REL RIIAD1 RNF6 RTP5 SCNM1 SHANK3 SMARCE1 SNAP91 SNTG2 SRPK2 SSX3 STMN3 TBC1D7 TCHP TSEN15 TSGA10IP TTC12 TXN2 UBE2I UBE2K USH1C UTP25 ZGPAT ZNF688
Entrez ID		5585	145282
HPRD ID		03019	06029
Ensembl ID		ENSG00000123143	ENSG00000151338
Uniprot IDs		Q16512	A0A8Q3SHY7 A8K735 G5EA54 Q4G0U7 Q8TD10
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion
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