PKN1 and MID2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PKN1	MID2
Description		protein kinase N1	midline 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex	Cytoplasm Cytoskeleton Microtubule Extracellular Exosome
	Molecular Function	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity	Transcription Coactivator Activity Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility	Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Viral Transcription Protein Localization To Microtubule Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Intracellular Signal Transduction
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1	237 interacting genes: ADAMTSL4 AEN ALDH3B1 ANKS1A AP1M1 AQP1 ARHGEF5 ATOSA ATOSB ATRIP AXIN1 BAHD1 BCL6B BLK BLZF1 BRCA1 BRMS1L BYSL C1orf35 CALCOCO2 CARD9 CARHSP1 CBX8 CCDC120 CCDC185 CCDC187 CCDC33 CCDC42 CCHCR1 CDK18 CEP57L1 CFP CHD2 CNNM3 COX5B CPSF4 CRACR2A CREBRF CTSZ DCX DGCR6 DGCR6L DMRT3 DRC4 DYDC1 EFHC2 EGFL7 EIF1AD ELOA ENKD1 EPN2 ETNK2 FAM107A FAM161A FAM161B FAM50B FAM90A1 FARS2 FASTKD5 FBF1 FBXL18 FBXW5 FOXD4L3 FRMD6 FSD2 GAS2L2 GCC1 GEM GFI1B GMCL1 GOLGA2 GOLGA7 GORASP2 GPANK1 GPKOW GSC2 HAPLN2 HCK HDAC4 HDX HNRNPLL HOXB2 HOXB5 HOXB9 IGBP1 IGFN1 IHO1 IKZF3 IL16 INO80B IQCN ISCU ITGB4 JOSD1 KANK2 KIF1A KIF9 KIFC3 KRT27 KRT31 KRT40 KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS8 LMNB2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LRRC45 LZTS1 LZTS2 MAGEA6 MAGOHB MEOX1 MEOX2 METTL17 MFAP1 MID1 MID1IP1 MOS MVP NCOA4 NR1D2 NSMF NXF1 OTUB2 PICK1 PKN1 POLDIP3 PPP1R18 PRDM16 PRPF3 PRPF31 PSMA1 PTCD2 PTPDC1 QARS1 RABGEF1 RANBP3L RCOR3 REL RLN1 RNF6 RORB RPH3AL RPP25L RUNX1T1 RXRB SCNM1 SDCBP SEPTIN1 SHFL SLC25A48 SLC25A6 SNAI1 SNAP47 SPAG5 SPATA24 SPG21 SPRY2 STX11 SYNGAP1 TASOR2 TBC1D22B TCAF1 TCEA2 TCEANC TEKT1 THAP7 TMEM14B TOP3B TRIM27 TRIM29 TRIM32 TRIM41 TRIM42 TRIM54 TRIM69 TRPV6 TSGA10 TTC23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K UBE2U UBTD1 UNC45A USP2 USP25 USP54 UTP23 UTP25 WT1-AS ZBTB16 ZBTB24 ZBTB42 ZC2HC1C ZFYVE21 ZGPAT ZIM2 ZNF124 ZNF165 ZNF177 ZNF24 ZNF250 ZNF266 ZNF408 ZNF410 ZNF417 ZNF438 ZNF440 ZNF451 ZNF497 ZNF552 ZNF559-ZNF177 ZNF564 ZNF587 ZNF648 ZNF669 ZNF688 ZNF696 ZNF764 ZNF774 ZNF784 ZNF785 ZNF792 ZRANB1 ZSCAN12
Entrez ID		5585	11043
HPRD ID		03019	02191
Ensembl ID		ENSG00000123143	ENSG00000080561
Uniprot IDs		Q16512	Q6GX22 Q9UJV3
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI	2DJA 2DMK 7QRZ
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion	Protein Binding Zinc Ion Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Ubiquitin Conjugating Enzyme Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Microtubule Binding Post-translational Protein Modification Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding Protein Polyubiquitination Cytoskeleton Negative Regulation Of RNA Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Protein Ubiquitination Regulation Of Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Identical Protein Binding
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