PKN1 and ARHGAP26

Number of citations of the paper that reports this interaction (PMID 11432776)
10

Data Source:
HPRD (in vivo, in vitro)

		PKN1	ARHGAP26
Gene Name		protein kinase N1	Rho GTPase activating protein 26
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow	Cellular_component Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	Rho GTPase Activator Activity Protein Binding Phospholipid Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility	Plasma Membrane Organization Small GTPase Mediated Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282	8 interactors: CDC42 CDC42EP2 INSR PKN1 PKN3 PTK2 RHOA SRPK1
Entrez ID		5585	23092
HPRD ID		03019	05643
Ensembl ID		ENSG00000123143	ENSG00000145819
Uniprot IDs		Q16512	Q9UNA1
PDB IDs		1CXZ 1URF 2RMK	1UGV
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Intracellular Signal Transduction Cell Migration Epithelial Cell Migration Epithelium Migration Ephrin Receptor Signaling Pathway Cell Motility Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Cell Division Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Establishment Of Nucleus Localization Positive Regulation Of Kinase Activity Regulation Of Cytoskeleton Organization Locomotion Ameboidal-type Cell Migration Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Positive Regulation Of Cell Cycle Process Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Nucleus Localization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Division Substantia Nigra Development Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokinesis Regulation Of Kinase Activity Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Organelle Organization Regulation Of Phosphatidylinositol 3-kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Phosphorylation Intracellular Signal Transduction
Tagcloud ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	ampar amphiphysin aqp4 biochip caspr2 comparably cv2 dner dppx gabar gad65 gad67 glra1b grm1 grm5 if1 lgl1 ma2 mog mosaics neuropsychiatrically nmdar1 questioning recoverin seroprevalence unambiguous upfront yo zic4
Tagcloud (Difference) ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	ampar amphiphysin aqp4 biochip caspr2 comparably cv2 dner dppx gabar gad65 gad67 glra1b grm1 grm5 if1 lgl1 ma2 mog mosaics neuropsychiatrically nmdar1 questioning recoverin seroprevalence unambiguous upfront yo zic4
Tagcloud (Intersection) ?