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PKN1 and ACTN1
Number of citations of the paper that reports this interaction (PubMedID
11802708
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
PKN1
ACTN1
Description
protein kinase N1
actinin alpha 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Membrane
Midbody
Cytoplasmic Vesicle
Cleavage Furrow
Protein-containing Complex
Stress Fiber
Ruffle
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Fascia Adherens
Focal Adhesion
Actin Cytoskeleton
Membrane
Sarcomere
Z Disc
Cell Junction
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Cell Projection
Synapse
Extracellular Exosome
Anchoring Junction
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Histone H3T11 Kinase Activity
Histone Binding
Histone Deacetylase Binding
Nuclear Androgen Receptor Binding
Protein Serine Kinase Activity
Transcription Coactivator Activity
Double-stranded RNA Binding
Actin Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Vinculin Binding
Identical Protein Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Metal Ion Binding
Actin Filament Binding
Structural Constituent Of Postsynapse
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Hyperosmotic Response
Signal Transduction
Epithelial Cell Migration
Negative Regulation Of B Cell Proliferation
Intracellular Signal Transduction
Post-translational Protein Modification
Positive Regulation Of DNA-templated Transcription
Spleen Development
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Cell Motility
Actin Filament Organization
Actin Cytoskeleton Organization
Platelet Activation
Platelet Formation
Platelet Morphogenesis
Regulation Of Apoptotic Process
Positive Regulation Of DNA-templated Transcription
Focal Adhesion Assembly
Anatomical Structure Formation Involved In Morphogenesis
Actin Filament Bundle Assembly
Actin Filament Network Formation
Muscle Cell Development
Platelet Aggregation
Postsynapse Organization
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RAC1 GTPase cycle
Platelet degranulation
Syndecan interactions
Nephrin family interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
RHOD GTPase cycle
RHOBTB2 GTPase cycle
RHOF GTPase cycle
Drugs
Fostamatinib
Human calcitonin
Copper
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Asthma (
31959851
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Feeling fed-up (
29500382
)
Feeling hurt (
29500382
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
)
High light scatter reticulocyte count (
32888494
)
Lack of perseverance (
30718321
)
Mean platelet volume (
27863252
32888494
)
Medication use (drugs used in diabetes) (
31015401
)
Mosquito bite size (
28199695
)
Neurociticism (
29500382
)
Periodontitis (Mean PAL) (
24024966
)
Platelet count (
29403010
26805783
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Prostate cancer (
23535732
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Smoking behavior (
19247474
)
Urinary albumin excretion (
30220432
)
Interacting Genes
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DNAAF19
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
RHOB
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
93 interacting genes:
ACTN3
ADORA2A
APC
APPBP2
ATXN2
ATXN7
CACNA1A
CAMK2A
CBY2
CDK5
CDK5R1
CDK5R2
CEBPA
CLIC5
COIL
COL17A1
CSRP1
CSRP3
CTNNA1
DDIAS
DSCAM
DYNLT1
EIF2S1
EPM2AIP1
ERBIN
FBP1
FILNC1
FXN
FXR1
GADD45G
GFI1B
GIPC1
GIT2
GRIA4
GRIN2A
GRM5
GTF2H1
HSPB1
ICAM5
ITGB1
KAT2B
KCTD6
KPNA2
LINC01554
LNX1
LPP
MAGEA11
MAP2
MAP3K1
MED14
MICALL2
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
MYOZ2
MYOZ3
NEBL
NKAPD1
NR1H3
NUMBL
OAS1
PALLD
PDHX
PDLIM1
PDLIM5
PIAS4
PKD1
PKN1
PLD2
PSEN1
PSMA1
PTK2
PTPN1
PTPN6
PYGB
RAVER1
RPS27
SIRPA
SLC2A4
SORBS2
SRC
SSX2IP
SYNPO2L
TES
TSC1
TTN
TXN
USP2
VCL
XRCC4
ZYX
Entrez ID
5585
87
HPRD ID
03019
00020
Ensembl ID
ENSG00000123143
ENSG00000072110
Uniprot IDs
Q16512
A0A024R694
A0A7I2V4Y4
A0A804HL31
A0A804HLF4
H9KV75
P12814
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
2EYI
2EYN
2N8Y
2N8Z
Enriched GO Terms of Interacting Partners
?
Cytoskeleton
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Intermediate Filament
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Organelle Organization
Keratin Filament
Morphogenesis Of An Epithelium
Structural Constituent Of Cytoskeleton
Cytosol
Identical Protein Binding
Structural Molecule Activity
Protein Binding
Tissue Morphogenesis
Microtubule Binding
Regulation Of Microtubule-based Process
Microtubule
Cytoplasm
Regulation Of Microtubule Cytoskeleton Organization
Centrosome
Epithelial Cell Differentiation
Developmental Process
Microtubule Cytoskeleton Organization
Epidermis Development
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Postsynaptic Intermediate Filament Cytoskeleton Organization
Neurofilament Bundle Assembly
Protein Localization To Cytoskeleton
Intermediate Filament Cytoskeleton
Cellular Component Assembly
Microtubule-based Process
Postsynaptic Intermediate Filament Cytoskeleton
Tumor Necrosis Factor Receptor Superfamily Complex
Cellular Developmental Process
Axon Development
Neurofibrillary Tangle
Regulation Of Synapse Maturation
Tumor Necrosis Factor Binding
Gamma-tubulin Binding
Intermediate Filament Bundle Assembly
Cell Projection Organization
Regulation Of Organelle Transport Along Microtubule
Response To Electrical Stimulus
Regulation Of Canonical NF-kappaB Signal Transduction
Neurofilament Cytoskeleton Organization
Thioesterase Binding
Focal Adhesion
Z Disc
Cell Adhesion
Cytoplasm
Actin Binding
Actin Cytoskeleton
Actinin Binding
Actin Cytoskeleton Organization
Telethonin Binding
Anchoring Junction
Actomyosin Structure Organization
Actin Filament-based Process
Cell-cell Adhesion
Cytoskeleton Organization
Sarcomere Organization
Structural Constituent Of Muscle
Focal Adhesion
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Stress Fiber
Cell Junction Organization
Cell Projection
Protein Kinase 5 Complex
Cell-substrate Adhesion
Regulation Of Protein Localization
Regulation Of Programmed Cell Death
Muscle Alpha-actinin Binding
Negative Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Dendritic Spine
FATZ Binding
Regulation Of Apoptotic Process
Cell-matrix Adhesion
Regulation Of Multicellular Organismal Process
Regulation Of Synaptic Transmission, Glutamatergic
Negative Regulation Of Cell Communication
Protein Binding
Negative Regulation Of Signaling
Neuronal Cell Body
Synaptic Transmission, Glutamatergic
Regulation Of Intracellular Signal Transduction
Detection Of Muscle Stretch
Organelle Organization
Protein Kinase Binding
Positive Regulation Of Apoptotic Process
Contractile Actin Filament Bundle Assembly
Stress Fiber Assembly
Regulation Of Generation Of Precursor Metabolites And Energy
Cadherin Binding
Cellular Response To Amyloid-beta
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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