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PKN1 and POU6F2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PKN1
POU6F2
Description
protein kinase N1
POU class 6 homeobox 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Membrane
Midbody
Cytoplasmic Vesicle
Cleavage Furrow
Protein-containing Complex
Chromatin
Nucleus
Molecular Function
Nucleotide Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Histone H3T11 Kinase Activity
Histone Binding
Histone Deacetylase Binding
Nuclear Androgen Receptor Binding
Protein Serine Kinase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Hyperosmotic Response
Signal Transduction
Epithelial Cell Migration
Negative Regulation Of B Cell Proliferation
Intracellular Signal Transduction
Post-translational Protein Modification
Positive Regulation Of DNA-templated Transcription
Spleen Development
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Cell Motility
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Central Nervous System Development
Visual Perception
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RAC1 GTPase cycle
Drugs
Fostamatinib
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Adult body size (
32376654
)
Attention deficit hyperactivity disorder (inattention symptoms) (
32595297
)
Caffeine consumption from tea (
33287642
)
Feeling hurt (
29500382
)
Glaucoma (multi-trait analysis) (
31959993
)
Glaucoma (primary open-angle) (
33627673
)
Hand grip strength (
29691431
)
Intraocular pressure (
29785010
30054594
31959993
)
Motion sickness (
25628336
)
Refractive error (
32231278
)
Tea consumption (
31046077
)
Interacting Genes
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DNAAF19
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
RHOB
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
143 interacting genes:
ACTN3
AIRIM
ANKRD10
ARHGEF6
ASB13
BANP
BFSP2
BHLHE40
C5
CCHCR1
CCNC
CCNK
CDC23
CDC37
CDKN2C
CHAF1A
CIB3
CINP
CSNK2A1
CSTF2
CTNNA3
DDX6
DTNB
DYDC1
EBF1
EIF3F
EIF4EBP1
EPHB6
FHL2
FNDC3B
FOSB
GCM2
GLIS2
GMEB2
GOLGA6L9
HGS
HIVEP1
HNF1B
HOXC5
HOXC8
HSPA4
IGFN1
IMPDH2
IQUB
IRX4
ISX
KDF1
KIF5B
KLHL11
KPNA5
KPNA6
KRTAP8-1
L3MBTL2
LARP4
LMNB2
LMO3
LNX1
LONRF1
MAGEA12
MAPK9
MEIS2
MIEN1
MLLT10
MORF4L2
MSRB3
MSX2
MYL7
MYO15B
NEUROG3
NFYC
NKX3-2
NME7
NUP62CL
OAZ3
OIP5
OPLAH
OPTN
PADI4
PARVG
PDE6H
PIBF1
PKN1
PM20D2
POLR3C
POU2F1
PPIL1
PPIP5K2
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QRICH1
RAD23B
RBM39
RBPMS
RELA
SIX1
SMAD5
SMYD1
SORL1
SOX10
SSUH2
STAC
STRA8
TBX6
TCEA2
TENT5B
THADA
THAP1
TLX2
TLX3
TNPO2
TNXB
TP53BP1
TRIM73
TRIML2
TSC1
TSEN15
TTC19
TTC23
UBAC1
UFSP1
VAX2
VENTX
VEZF1
VPS9D1
XPOT
ZBTB24
ZBTB4
ZFHX2
ZFHX3
ZFP1
ZFP91
ZIM2
ZMYND12
ZNF148
ZNF319
ZNF34
ZNF384
ZNF410
ZNF574
Entrez ID
5585
11281
HPRD ID
03019
10162
Ensembl ID
ENSG00000123143
ENSG00000106536
Uniprot IDs
Q16512
A0A6E1XZL4
P78424
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
?
Cytoskeleton
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Intermediate Filament
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Organelle Organization
Keratin Filament
Morphogenesis Of An Epithelium
Structural Constituent Of Cytoskeleton
Cytosol
Identical Protein Binding
Structural Molecule Activity
Protein Binding
Tissue Morphogenesis
Microtubule Binding
Regulation Of Microtubule-based Process
Microtubule
Cytoplasm
Regulation Of Microtubule Cytoskeleton Organization
Centrosome
Epithelial Cell Differentiation
Developmental Process
Microtubule Cytoskeleton Organization
Epidermis Development
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Postsynaptic Intermediate Filament Cytoskeleton Organization
Neurofilament Bundle Assembly
Protein Localization To Cytoskeleton
Intermediate Filament Cytoskeleton
Cellular Component Assembly
Microtubule-based Process
Postsynaptic Intermediate Filament Cytoskeleton
Tumor Necrosis Factor Receptor Superfamily Complex
Cellular Developmental Process
Axon Development
Neurofibrillary Tangle
Regulation Of Synapse Maturation
Tumor Necrosis Factor Binding
Gamma-tubulin Binding
Intermediate Filament Bundle Assembly
Cell Projection Organization
Regulation Of Organelle Transport Along Microtubule
Response To Electrical Stimulus
Regulation Of Canonical NF-kappaB Signal Transduction
Neurofilament Cytoskeleton Organization
Thioesterase Binding
Focal Adhesion
Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleus
Sequence-specific Double-stranded DNA Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Protein Binding
Chromatin
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Pattern Specification Process
Negative Regulation Of DNA-templated Transcription
Sequence-specific DNA Binding
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Zinc Ion Binding
Transcription Cis-regulatory Region Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Branch Elongation Involved In Ureteric Bud Branching
Stem Cell Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nuclear Import Signal Receptor Activity
Animal Organ Development
Activation Of Meiosis
Nuclear Localization Sequence Binding
DNA-templated Transcription
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Tagcloud (Intersection)
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