PKN1 and NEUROD2

Number of citations of the paper that reports this interaction (PMID 10640683)
3

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		PKN1	NEUROD2
Gene Name		protein kinase N1	neuronal differentiation 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow	Nucleus
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Heterodimerization Activity E-box Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility	Behavioral Fear Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Associative Learning Protein Ubiquitination Cerebellar Cortex Development Positive Regulation Of Synaptic Plasticity Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Development Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Synapse Maturation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Synapse Maturation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282	2 interactors: PKN1 TK1
Entrez ID		5585	4761
HPRD ID		03019	03429
Ensembl ID		ENSG00000123143
Uniprot IDs		Q16512	Q15784
PDB IDs		1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process	Fetal Process Involved In Parturition Skeletal Muscle Cell Proliferation Thymidine Metabolic Process Response To Cortisol Histone H3-T11 Phosphorylation Deoxyribonucleoside Monophosphate Biosynthetic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Parturition Response To Copper Ion Hyperosmotic Response Pyrimidine Nucleobase Metabolic Process Activation Of JUN Kinase Activity Histone Phosphorylation Peptidyl-threonine Phosphorylation Pyrimidine Nucleoside Biosynthetic Process Protein Homotetramerization Pyrimidine Nucleoside Metabolic Process Positive Regulation Of JUN Kinase Activity Phosphorylation Regulation Of JUN Kinase Activity JNK Cascade Response To Osmotic Stress Epithelial Cell Migration Nucleoside Monophosphate Biosynthetic Process Epithelium Migration Protein Tetramerization DNA Biosynthetic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Digestive Tract Development Activation Of MAPK Activity Digestive System Development Liver Development Response To Glucocorticoid Regulation Of JNK Cascade Response To Corticosteroid Response To Toxic Substance Phosphate-containing Compound Metabolic Process Ameboidal-type Cell Migration Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	boosts conversion converts currents depletion exhibit express fibroblast fibroblasts find generate instead lineages neural parental passage potentials replacement robust successfully surprisingly transmitter tumorigenic turn understand upregulates
Tagcloud (Difference) ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	boosts conversion converts currents depletion exhibit express fibroblast fibroblasts find generate instead lineages neural parental passage potentials replacement robust successfully surprisingly transmitter tumorigenic turn understand upregulates
Tagcloud (Intersection) ?