PKN1 and SPRR2D

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PKN1	SPRR2D
Gene Name		protein kinase N1	small proline-rich protein 2D
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow	Cornified Envelope Cytoplasm
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility	Epidermis Development Keratinization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282	2 interactors: MAPK6 PKN1
Entrez ID		5585	6703
HPRD ID		03019
Ensembl ID		ENSG00000123143	ENSG00000163216
Uniprot IDs		Q16512	P22532
PDB IDs		1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process	MAPK Cascade Signal Transduction By Phosphorylation Histone H3-T11 Phosphorylation Hyperosmotic Response
Tagcloud ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?