PKN1 and MARCKS

Number of citations of the paper that reports this interaction (PMID 8557118)
4

Data Source:
HPRD (in vitro)

		PKN1	MARCKS
Gene Name		protein kinase N1	myristoylated alanine-rich protein kinase C substrate
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow	Centrosome Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Germinal Vesicle Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	Protein Kinase C Binding Calmodulin Binding Actin Filament Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility	Energy Reserve Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion
Pathways			Acetylcholine regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282	13 interactors: CALM2 CCNE1 CDK1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB PRKCZ SPP1 TOB1
Entrez ID		5585	4082
HPRD ID		03019	07519
Ensembl ID		ENSG00000123143	ENSG00000155130
Uniprot IDs		Q16512	P29966
PDB IDs		1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process	Histone Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Regulation Of Protein Kinase Activity Phosphorylation Regulation Of Kinase Activity Cellular Response To Stimulus Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Cell Communication Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Rhodopsin Mediated Signaling Pathway Mitotic Cell Cycle Process Response To Stress Mitotic Nuclear Envelope Disassembly Response To Wounding Positive Regulation Of Cellular Metabolic Process Chromatin Organization Response To Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Intracellular Signal Transduction Mitotic Cell Cycle Histone Modification Nuclear Envelope Disassembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Blood Coagulation Hemostasis Phosphate-containing Compound Metabolic Process Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Response To Hormone Peptidyl-amino Acid Modification Nuclear Envelope Organization Positive Regulation Of Phospholipase Activity Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Response To Insulin Stimulus Chromosome Organization Mitotic Cell Cycle Phase Transition
Tagcloud ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds
Tagcloud (Difference) ?		accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5	approximate brainstem bulb ca1 ca3 callosum cerebellar corpus cortices declined entorhinal filamentous fimbria fornix granule habenula hilus medial mrp myristoylated neocortex olfactory p1 p14 p7 phosphoproteins purkinje thalamus thirds
Tagcloud (Intersection) ?