PCK1 and FBXO25

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		PCK1	FBXO25
Gene Name		phosphoenolpyruvate carboxykinase 1 (soluble)	F-box protein 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Internal Protein Amino Acid Acetylation Pathogenesis Response To Activity Drug Metabolic Process Response To Insulin Glucose Homeostasis Small Molecule Metabolic Process Glycerol Biosynthetic Process From Pyruvate	Protein Ubiquitination
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Transcriptional regulation of white adipocyte differentiation Glycogen storage diseases Metabolism of carbohydrates Abacavir transport and metabolism Abacavir metabolism
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine Phosphomethylphosphonic Acid-Guanylate Ester
Diseases
GWAS		Response to fenofibrate (adiponectin levels) ( 23149075) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		4 interactors: APP C1R FBXO25 IKBKG	80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		5105	26260
HPRD ID		02028	16439
Ensembl ID		ENSG00000124253	ENSG00000147364
Uniprot IDs		B4DT64 P35558	Q8TCJ0
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Synaptic Growth At Neuromuscular Junction Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Immune Response Defense Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling	Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process
Tagcloud ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite picture preferential pyruvate redundant repressive suppressing tcf tcf7l2 tcf7l2dn views wnt
Tagcloud (Difference) ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite picture preferential pyruvate redundant repressive suppressing tcf tcf7l2 tcf7l2dn views wnt
Tagcloud (Intersection) ?