PCK1 and IKBKG

Number of citations of the paper that reports this interaction (PubMedID 20098747)
50

Data Source:
BioGRID (pull down)

		PCK1	IKBKG
Description		phosphoenolpyruvate carboxykinase 1	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding Kinase Activity Transferase Activity Lyase Activity Carboxy-lyase Activity Purine Nucleotide Binding Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding Protein Serine Kinase Activity (using GTP As Donor)	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding
	Biological Process	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Response To Bacterium Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP-SCAP Complex Retention In Endoplasmic Reticulum Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Dicarboxylic Acid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Glyceraldehyde-3-phosphate Biosynthetic Process Glycerol Biosynthetic Process From Pyruvate Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Protein Maturation Hepatocyte Differentiation Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Tricarboxylic Acid Metabolic Process	B Cell Homeostasis Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Immune Response DNA Damage Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Macroautophagy Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Establishment Of Vesicle Localization Protein-containing Complex Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate	AGRO100 Tarenflurbil
Diseases			Incontinentia pigmenti Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS		Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)	Hemoglobin levels ( 26366553)
Interacting Genes		8 interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 UBR5	241 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BRME1 C19orf12 CALB1 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAPRE1 MARCHF2 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKDC PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF34 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNF TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3
Entrez ID		5105	8517
HPRD ID		02028	02217
Ensembl ID		ENSG00000124253	ENSG00000269335
Uniprot IDs		P35558	A0A087X1B1 Q9Y6K9
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV	2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4 6XX0 6YEK 7T2U 7TV4 8U7C 9AZJ
Enriched GO Terms of Interacting Partners?		SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Cholesterol Biosynthetic Process NLS-bearing Protein Import Into Nucleus Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Steroid Biosynthetic Process SREBP-SCAP-Insig Complex Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Cholesterol Metabolic Process Maintenance Of Protein Location In Cell Regulation Of Cellular Response To Stress Maintenance Of Protein Location Nuclear Transport Nucleocytoplasmic Transport Maintenance Of Location In Cell Cranial Suture Morphogenesis Maintenance Of Location Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Response To Endoplasmic Reticulum Stress Protein Maturation Response To Sterol Depletion Anoikis Regulation Of Small Molecule Metabolic Process Cellular Response To Insulin Stimulus Protein K29-linked Ubiquitination Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Small Molecule Metabolic Process Oxysterol Binding Protein Import Into Nucleus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Import Into Nucleus Establishment Of Localization In Cell Craniofacial Suture Morphogenesis Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Protein Kinase Activity Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytosol Canonical NF-kappaB Signal Transduction Kinase Activity Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Activation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Protein Modification Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Macromolecule Metabolic Process Protein Tyrosine Kinase Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Protein Phosphorylation Protein Binding Regulation Of Protein Modification Process Protein Metabolic Process ATP Binding Negative Regulation Of Programmed Cell Death Phosphorylation Nucleus
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