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ITSN1 and MAPK8IP2
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
ITSN1
MAPK8IP2
Gene Name
intersectin 1 (SH3 domain protein)
mitogen-activated protein kinase 8 interacting protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Coated Pit
Lamellipodium
Cell Junction
Endocytic Vesicle
Neuron Projection
Synapse
Cytoplasm
Neuronal Cell Body
Protein Complex
Neuronal Postsynaptic Density
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Protein Binding
Kinase Activator Activity
Protein Complex Scaffold
Proline-rich Region Binding
Beta-amyloid Binding
MAP-kinase Scaffold Activity
Structural Molecule Activity
Protein Binding
Kinesin Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Protein Complex Binding
Biological Process
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Synaptic Vesicle Endocytosis
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
MAPK Cascade
Behavioral Fear Response
Signal Complex Assembly
JNK Cascade
Mating Behavior
Regulation Of Receptor Activity
Positive Regulation Of Stress-activated MAPK Cascade
Social Behavior
Positive Regulation Of Protein Kinase Activity
Regulation Of JNK Cascade
Nonassociative Learning
Dendrite Morphogenesis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
EPHB-mediated forward signaling
GPCR downstream signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions
82 interactors:
AGFG1
AGFG2
AP2B1
ARF6
ARFIP2
ARHGAP31
ASAP2
CCNO
CDC42
CEP85L
CLIP2
CLTC
CSNK2B
CYTH1
DAB2
DES
DISC1
DLGAP1
DNM1
DNM2
EEF1A1
EPHB2
EPN2
EPS15
EPS15L1
FCHSD2
FNBP1
FNBP4
GAREML
GCC1
GOLGA5
HIP1
HRAS
ITSN2
KHDRBS1
KIF16B
KIF5A
LMO4
MAPK6
MAPK8IP2
MRPL20
MTUS2
PACSIN3
PDCD6IP
PFDN5
PICALM
PIK3AP1
PIK3C2B
PIK3R1
PLK1
PPFIA2
PPL
PREX1
RAB11FIP2
RAB5A
RABEP1
RAI14
RNF40
RPS6KA5
SCAMP1
SCOC
SF3B4
SH3GL2
SMARCC2
SNAP23
SNAP25
SNX5
SOS1
SPDL1
SPRY2
STON2
SYNJ1
SYNJ2
TK1
TRIM8
TSG101
UBE2K
UNC119
WASL
WBP11
ZAK
ZFPM2
52 interactors:
ADRB2
AFG3L2
APP
ASRGL1
BBS10
C14orf1
CFL1
CHN1
CRMP1
DUSP16
EGFR
ERBB2
EZH2
FGF12
FSCN1
GBP2
ITSN1
KIFC2
KLC1
LRP1
LRP2
LRP8
MAGED4B
MAP2K3
MAP2K7
MAP3K10
MAP3K11
MAP3K12
MAPK10
MAPK8
MAPK8IP1
MAPK8IP3
MAPK9
MASP1
NDUFS6
PLXNA3
PRSS23
RAI1
RBX1
RPS6KB2
SMARCB1
SMS
SYNE2
TIAM1
TP53BP2
UNC119
VCP
VPS33B
VRK2
YY1AP1
ZNF593
ZNF784
Entrez ID
6453
23542
HPRD ID
03898
09674
Ensembl ID
ENSG00000205726
ENSG00000008735
Uniprot IDs
A7XZY7
F8W7U0
Q15811
Q6PD56
Q13387
PDB IDs
1KI1
2KGR
2KHN
3FIA
3QBV
4IIM
Enriched GO Terms of Interacting Partners
?
Vesicle-mediated Transport
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Endocytosis
Vesicle Organization
Cellular Localization
Establishment Of Localization In Cell
Regulation Of Vesicle-mediated Transport
Signaling
Synaptic Transmission
Regulation Of Cellular Component Organization
Establishment Of Organelle Localization
Cell Communication
Regulation Of Signaling
Organelle Organization
Protein Localization
Cell Differentiation
Synaptic Vesicle Transport
Cell-cell Signaling
Membrane Budding
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Organelle Localization
Regulation Of ERBB Signaling Pathway
Positive Regulation Of Metabolic Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neuron Projection Morphogenesis
Negative Regulation Of ERBB Signaling Pathway
Post-Golgi Vesicle-mediated Transport
Establishment Of Vesicle Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Vesicle Localization
Transport
Cell Morphogenesis Involved In Neuron Differentiation
Axon Guidance
Generation Of Neurons
Cell Morphogenesis Involved In Differentiation
Membrane Organization
Cell Projection Morphogenesis
Cell Part Morphogenesis
Establishment Of Protein Localization
Cell Projection Organization
Synaptic Vesicle Recycling
Axonogenesis
Cellular Protein Complex Assembly
Neurogenesis
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Intracellular Transport
Cell Morphogenesis
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
JNK Cascade
Signal Transduction By Phosphorylation
MAPK Cascade
Regulation Of Protein Kinase Activity
Regulation Of MAPK Cascade
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
JUN Phosphorylation
Regulation Of MAP Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Signal Transduction
Positive Regulation Of MAP Kinase Activity
Response To Stress
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of MAPK Cascade
Regulation Of Signal Transduction
Response To Light Stimulus
Response To External Stimulus
Response To Radiation
Regulation Of Signaling
Intracellular Signal Transduction
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Axon Guidance
Regulation Of Intracellular Signal Transduction
Signal Transduction
Axonogenesis
Phosphorylation
Cell Part Morphogenesis
Axon Development
Response To Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Response To Abiotic Stimulus
Protein Phosphorylation
Cellular Response To Stress
Signaling
Tagcloud
?
cbr1
david
degs
downloaded
dyrk1a
egr1
encyclopedia
geo
gse
hmgn1
hypergeometric
interrogate
kegg
kyoto
macromolecular
multiarray
mycmax
mzf1
nfe2
nfy
olf1
ominibus
pax5
rma
rp58
son
srebp1
tmem50b
ttc3
Tagcloud (Difference)
?
cbr1
david
degs
downloaded
dyrk1a
egr1
encyclopedia
geo
gse
hmgn1
hypergeometric
interrogate
kegg
kyoto
macromolecular
multiarray
mycmax
mzf1
nfe2
nfy
olf1
ominibus
pax5
rma
rp58
son
srebp1
tmem50b
ttc3
Tagcloud (Intersection)
?