ITSN1 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ITSN1	SPTAN1
Description		intersectin 1	spectrin alpha, non-erythrocytic 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Endomembrane System Membrane Lamellipodium Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Recycling Endosome Apical Dendrite Intracellular Vesicle Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Molecular Adaptor Activity Proline-rich Region Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Exocytosis Endocytosis Intracellular Protein Localization Regulation Of Cell Communication Protein Transport Endosomal Transport Regulation Of Signaling Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Tonsillectomy ( 27182965 28928442)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		140 interacting genes: AGFG1 AGFG2 AJUBA ANKRD36 ANKRD54 ARF6 ARFIP2 ARHGAP31 ASAP2 BECN1 BFSP1 BRCC3 BRWD3 CCDC24 CCNO CDC42 CEP85L CLIP2 CLTC COG4 CSNK2B CYTH1 CYTH3 DAB1 DAB2 DES DISC1 DLGAP1 DNAI7 DNAJA2 DNM1 DNM2 DST DYNC1H1 EEF1A1 EPHB2 EPN2 EPS15 EXOC1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GFAP GNPTG GOLGA5 HIP1 HNRNPK HRAS IFT74 ITSN2 KHDRBS1 KIF16B KIF5A KIF5C KRT222 LMO3 LMO4 MAP3K20 MAPK6 MAPK8IP2 MED4 MRPL20 MTUS2 MYH14 NASP NEFL NEFM NEMF PACSIN3 PDCD6IP PDE2A PDZD8 PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RALBP1 REPS1 REPS2 RIN1 RNF40 RPS6KA5 RRBP1 SCAI SCAMP1 SCOC SF3B4 SH3GL2 SHANK3 SIAH1 SMARCC2 SMC1A SNAP23 SNAP25 SNRNP70 SNX5 SNX6 SOS1 SOS2 SPDL1 SPECC1 SPRY2 SPTAN1 SPTBN1 STON2 SYNC SYNE1 SYNJ1 SYNJ2 TK1 TRAF3IP1 TRIM5 TRIM8 TRPM7 TSG101 TTC27 UBC UBE2K UNC119 VLDLR WASL WBP11 WHAMM ZFC3H1 ZFPM2 ZMYM5	60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333
Entrez ID		6453	6709
HPRD ID		03898	01684
Ensembl ID		ENSG00000205726	ENSG00000197694
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T	2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Import Into Cell Cytoplasm Cytosol Establishment Of Localization In Cell Clathrin-coated Pit Clathrin Coat Assembly Cytoskeleton Organization Organelle Organization Cytoskeleton Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Organelle Localization Membrane Organization Cellular Component Assembly Clathrin-coated Vesicle Protein Transport Clathrin-dependent Endocytosis Intermediate Filament-based Process Cellular Localization Establishment Of Organelle Localization Intracellular Transport Negative Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Establishment Of Protein Localization Regulation Of Protein Localization To Cell Periphery Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intracellular Protein Localization Protein-containing Complex Assembly Clathrin Coat Of Coated Pit Intermediate Filament Cytoskeleton Protein-containing Complex Organization Structural Constituent Of Cytoskeleton Post-Golgi Vesicle-mediated Transport Glutamatergic Synapse Microtubule Binding Establishment Of Vesicle Localization Endosomal Transport Cell Cortex Cytoplasmic Vesicle Golgi Vesicle Transport Regulation Of Protein Localization To Plasma Membrane Vesicle Localization Cytoskeleton-dependent Intracellular Transport Cell Projection Organization Mitotic Cytokinesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite
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