ITSN1 and FNBP1

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN1	FNBP1
Gene Name		intersectin 1 (SH3 domain protein)	formin binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse	Lysosome Cytoskeleton Plasma Membrane Coated Pit Cell Cortex Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Endocytosis
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2	13 interactors: AKAP9 ARHGAP17 CBL CDC42 DNM1 DNM2 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL
Entrez ID		6453	23048
HPRD ID		03898	10446
Ensembl ID		ENSG00000205726	ENSG00000187239
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	B7ZL12 B7ZL13 B7ZL14 Q96RU3
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM	2EFL
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Signal Transduction Ephrin Receptor Signaling Pathway Negative Regulation Of Membrane Tubulation Signaling Cell Communication Endocytosis Cellular Response To Stimulus Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Neuron Projection Morphogenesis Cell Projection Organization Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Establishment Of Organelle Localization Response To Stimulus Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Organelle Localization Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cell-cell Signaling Generation Of Neurons Regulation Of Catalytic Activity Neuron Development Regulation Of Cell Projection Organization Nitric Oxide Metabolic Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Neurogenesis Reactive Nitrogen Species Metabolic Process Endosome Organization Axonogenesis Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Regulation Of Intracellular Signal Transduction Vesicle Localization Positive Regulation Of Receptor-mediated Endocytosis Axon Development Regulation Of Nitric-oxide Synthase Activity Anatomical Structure Development Response To External Stimulus
Tagcloud ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	11p 12p 17q11 6q16 9p21 9q34 af10 c9orf78 calm concurring cryptic del grik2 hoxa imbalances immunophenotyping interphase inup214 leukemias lymphoblastic nup214 q11 q12 q34 q35 taf tcrb tlx3 usp20
Tagcloud (Difference) ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	11p 12p 17q11 6q16 9p21 9q34 af10 c9orf78 calm concurring cryptic del grik2 hoxa imbalances immunophenotyping interphase inup214 leukemias lymphoblastic nup214 q11 q12 q34 q35 taf tcrb tlx3 usp20
Tagcloud (Intersection) ?