ITSN1 and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid, protein complementation assay, affinity chromatography technology)

		ITSN1	ARFIP2
Description		intersectin 1	ARF interacting protein 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Endomembrane System Membrane Lamellipodium Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Recycling Endosome Apical Dendrite Intracellular Vesicle Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Ruffle Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Trans-Golgi Network Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Molecular Adaptor Activity Proline-rich Region Binding	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Exocytosis Endocytosis Intracellular Protein Localization Regulation Of Cell Communication Protein Transport Endosomal Transport Regulation Of Signaling Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis	Mitophagy Intracellular Protein Transport Autophagy Small GTPase-mediated Signal Transduction Intracellular Protein Localization Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Phagophore Assembly Site
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Tonsillectomy ( 27182965 28928442)	Malaria ( 31844061)
Interacting Genes		140 interacting genes: AGFG1 AGFG2 AJUBA ANKRD36 ANKRD54 ARF6 ARFIP2 ARHGAP31 ASAP2 BECN1 BFSP1 BRCC3 BRWD3 CCDC24 CCNO CDC42 CEP85L CLIP2 CLTC COG4 CSNK2B CYTH1 CYTH3 DAB1 DAB2 DES DISC1 DLGAP1 DNAI7 DNAJA2 DNM1 DNM2 DST DYNC1H1 EEF1A1 EPHB2 EPN2 EPS15 EXOC1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GFAP GNPTG GOLGA5 HIP1 HNRNPK HRAS IFT74 ITSN2 KHDRBS1 KIF16B KIF5A KIF5C KRT222 LMO3 LMO4 MAP3K20 MAPK6 MAPK8IP2 MED4 MRPL20 MTUS2 MYH14 NASP NEFL NEFM NEMF PACSIN3 PDCD6IP PDE2A PDZD8 PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RALBP1 REPS1 REPS2 RIN1 RNF40 RPS6KA5 RRBP1 SCAI SCAMP1 SCOC SF3B4 SH3GL2 SHANK3 SIAH1 SMARCC2 SMC1A SNAP23 SNAP25 SNRNP70 SNX5 SNX6 SOS1 SOS2 SPDL1 SPECC1 SPRY2 SPTAN1 SPTBN1 STON2 SYNC SYNE1 SYNJ1 SYNJ2 TK1 TRAF3IP1 TRIM5 TRIM8 TRPM7 TSG101 TTC27 UBC UBE2K UNC119 VLDLR WASL WBP11 WHAMM ZFC3H1 ZFPM2 ZMYM5	61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1
Entrez ID		6453	23647
HPRD ID		03898	07209
Ensembl ID		ENSG00000205726	ENSG00000132254
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Import Into Cell Cytoplasm Cytosol Establishment Of Localization In Cell Clathrin-coated Pit Clathrin Coat Assembly Cytoskeleton Organization Organelle Organization Cytoskeleton Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Organelle Localization Membrane Organization Cellular Component Assembly Clathrin-coated Vesicle Protein Transport Clathrin-dependent Endocytosis Intermediate Filament-based Process Cellular Localization Establishment Of Organelle Localization Intracellular Transport Negative Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Establishment Of Protein Localization Regulation Of Protein Localization To Cell Periphery Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intracellular Protein Localization Protein-containing Complex Assembly Clathrin Coat Of Coated Pit Intermediate Filament Cytoskeleton Protein-containing Complex Organization Structural Constituent Of Cytoskeleton Post-Golgi Vesicle-mediated Transport Glutamatergic Synapse Microtubule Binding Establishment Of Vesicle Localization Endosomal Transport Cell Cortex Cytoplasmic Vesicle Golgi Vesicle Transport Regulation Of Protein Localization To Plasma Membrane Vesicle Localization Cytoskeleton-dependent Intracellular Transport Cell Projection Organization Mitotic Cytokinesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Transport Regulation Of Endocytosis GTPase Activity Cellular Localization Protein Binding Protein Transport Regulation Of Receptor-mediated Endocytosis GTP Binding Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization Organelle Organization Regulation Of Postsynapse Organization Cerebral Cortex GABAergic Interneuron Development Intracellular Transport Regulation Of Organelle Organization Regulation Of Cellular Localization Membrane Organization Positive Regulation Of Establishment Of Protein Localization Intracellular Protein Transport Cortical Cytoskeleton Organization Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Intracellular Protein Localization PTB Domain Binding Regulation Of Dendritic Spine Development Respiratory Burst Lamellipodium Golgi Vesicle Transport Establishment Of Localization In Cell Positive Regulation Of Secretion By Cell Regulation Of Synapse Organization Negative Regulation Of Endocytosis Regulation Of Establishment Of Protein Localization Regulation Of Cytoskeleton Organization Synaptic Vesicle Membrane Erythrocyte Enucleation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Secretion Regulation Of Receptor Internalization Postsynapse Cytoskeleton Organization Negative Regulation Of Receptor-mediated Endocytosis Endocytosis Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Mitotic Cytokinetic Process
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