ITSN1 and ARHGAP31

Number of citations of the paper that reports this interaction (PMID 11744688)
14

Data Source:
HPRD (in vitro, in vivo)

		ITSN1	ARHGAP31
Gene Name		intersectin 1 (SH3 domain protein)	Rho GTPase activating protein 31
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse	Cytosol Focal Adhesion Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding	GTPase Activator Activity SH3 Domain Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Schizophrenia ( 23894747)
Protein-Protein Interactions		82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2	5 interactors: CDC42 ITSN1 RAC1 SMURF1 TGFBR1
Entrez ID		6453	57514
HPRD ID		03898	16697
Ensembl ID		ENSG00000205726	ENSG00000031081
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	Q2M1Z3
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis	Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Cell Projection Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Signal Transduction Neuron Differentiation Regulation Of Filopodium Assembly Locomotion Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Phosphorylation Regulation Of Lipid Kinase Activity Cell Differentiation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Positive Regulation Of DNA Replication Regulation Of Cell Projection Organization Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Generation Of Neurons T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Neuron Fate Commitment Axonogenesis Neurogenesis Positive Regulation Of Transferase Activity Axon Development Tissue Development Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	1285t 4487g 5965g adams aos aplasia asp1989asn bilaterally bony cutis cys1496tyr cys429arg daughter dock6 eogt father fifth keeping multicellular notch notch1 oliver probands rbpj reinforces scalp symmetric transverse vasculopathy
Tagcloud (Difference) ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	1285t 4487g 5965g adams aos aplasia asp1989asn bilaterally bony cutis cys1496tyr cys429arg daughter dock6 eogt father fifth keeping multicellular notch notch1 oliver probands rbpj reinforces scalp symmetric transverse vasculopathy
Tagcloud (Intersection) ?