ITSN1 and CYTH1

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN1	CYTH1
Gene Name		intersectin 1 (SH3 domain protein)	cytohesin 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Polarity
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2	12 interactors: ACTA1 ARF1 ARF6 ARFRP1 ARR3 CYTIP GNAQ IPCEF1 ITGB2 ITSN1 PRKCD TRIM23
Entrez ID		6453	9267
HPRD ID		03898	01630
Ensembl ID		ENSG00000205726	ENSG00000108669
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	Q15438
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM	1BC9 4A4P
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis	Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Filopodium Assembly Regulation Of Phosphorylation Cell Communication Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Lipase Activity Regulation Of Actin Filament-based Process Protein Stabilization Positive Regulation Of Phospholipid Catabolic Process Skeletal Muscle Fiber Adaptation Apoptotic Process Blood Coagulation Hemostasis Programmed Cell Death Lymphocyte Proliferation Cell Death Mononuclear Cell Proliferation Death Regulation Of Protein Phosphorylation Interleukin-10 Production Regulation Of Cell Projection Assembly Leukocyte Proliferation Regulation Of Cytoskeleton Organization Negative Regulation Of Filopodium Assembly Regulation Of Protein Stability Interleukin-12 Production Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Ceramide Biosynthetic Process Wound Healing Skeletal Muscle Thin Filament Assembly Regulation Of Actin Filament Polymerization Embryonic Morphogenesis Endocytosis
Tagcloud ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?