ITSN1 and PIK3C2B

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		ITSN1	PIK3C2B
Gene Name		intersectin 1 (SH3 domain protein)	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse	Nucleus Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Endocytic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Biological_process Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events	Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS			Breast cancer ( 23535733) Prostate cancer ( 23535732)
Protein-Protein Interactions		82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2	9 interactors: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 YWHAQ
Entrez ID		6453	5287
HPRD ID		03898	04160
Ensembl ID		ENSG00000205726	ENSG00000133056
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	A2RUF7 F5GWN5 O00750
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Chemotaxis Regulation Of MAPK Cascade Locomotion Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Phosphorylation System Development Regulation Of Immune Response Axon Guidance Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Multicellular Organismal Development Cell Surface Receptor Signaling Pathway
Tagcloud ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Difference) ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Intersection) ?