ITSN1 and RAI14

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid)

		ITSN1	RAI14
Description		intersectin 1	retinoic acid induced 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Endomembrane System Membrane Lamellipodium Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Recycling Endosome Apical Dendrite Intracellular Vesicle Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Fibrillar Center Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cell Cortex Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Molecular Adaptor Activity Proline-rich Region Binding	Actin Binding Protein Binding
	Biological Process	Exocytosis Endocytosis Intracellular Protein Localization Regulation Of Cell Communication Protein Transport Endosomal Transport Regulation Of Signaling Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis	Spermatogenesis Cell Differentiation
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Tonsillectomy ( 27182965 28928442)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31152163 31451708 31015462 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Left ventricular mass ( 19454037) Platelet count ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 31578528) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
Interacting Genes		140 interacting genes: AGFG1 AGFG2 AJUBA ANKRD36 ANKRD54 ARF6 ARFIP2 ARHGAP31 ASAP2 BECN1 BFSP1 BRCC3 BRWD3 CCDC24 CCNO CDC42 CEP85L CLIP2 CLTC COG4 CSNK2B CYTH1 CYTH3 DAB1 DAB2 DES DISC1 DLGAP1 DNAI7 DNAJA2 DNM1 DNM2 DST DYNC1H1 EEF1A1 EPHB2 EPN2 EPS15 EXOC1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GFAP GNPTG GOLGA5 HIP1 HNRNPK HRAS IFT74 ITSN2 KHDRBS1 KIF16B KIF5A KIF5C KRT222 LMO3 LMO4 MAP3K20 MAPK6 MAPK8IP2 MED4 MRPL20 MTUS2 MYH14 NASP NEFL NEFM NEMF PACSIN3 PDCD6IP PDE2A PDZD8 PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RALBP1 REPS1 REPS2 RIN1 RNF40 RPS6KA5 RRBP1 SCAI SCAMP1 SCOC SF3B4 SH3GL2 SHANK3 SIAH1 SMARCC2 SMC1A SNAP23 SNAP25 SNRNP70 SNX5 SNX6 SOS1 SOS2 SPDL1 SPECC1 SPRY2 SPTAN1 SPTBN1 STON2 SYNC SYNE1 SYNJ1 SYNJ2 TK1 TRAF3IP1 TRIM5 TRIM8 TRPM7 TSG101 TTC27 UBC UBE2K UNC119 VLDLR WASL WBP11 WHAMM ZFC3H1 ZFPM2 ZMYM5	8 interacting genes: FEZ1 FEZ2 ITSN1 TTC3 USP7 YWHAB YWHAG YWHAQ
Entrez ID		6453	26064
HPRD ID		03898	09416
Ensembl ID		ENSG00000205726	ENSG00000039560
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	Q9P0K7
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Import Into Cell Cytoplasm Cytosol Establishment Of Localization In Cell Clathrin-coated Pit Clathrin Coat Assembly Cytoskeleton Organization Organelle Organization Cytoskeleton Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Organelle Localization Membrane Organization Cellular Component Assembly Clathrin-coated Vesicle Protein Transport Clathrin-dependent Endocytosis Intermediate Filament-based Process Cellular Localization Establishment Of Organelle Localization Intracellular Transport Negative Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Establishment Of Protein Localization Regulation Of Protein Localization To Cell Periphery Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intracellular Protein Localization Protein-containing Complex Assembly Clathrin Coat Of Coated Pit Intermediate Filament Cytoskeleton Protein-containing Complex Organization Structural Constituent Of Cytoskeleton Post-Golgi Vesicle-mediated Transport Glutamatergic Synapse Microtubule Binding Establishment Of Vesicle Localization Endosomal Transport Cell Cortex Cytoplasmic Vesicle Golgi Vesicle Transport Regulation Of Protein Localization To Plasma Membrane Vesicle Localization Cytoskeleton-dependent Intracellular Transport Cell Projection Organization Mitotic Cytokinesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Negative Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Protein Domain Specific Binding Protein Targeting Regulation Of Intracellular Transport Protein Sequestering Activity Protein Kinase C Binding Negative Regulation Of Macroautophagy Regulation Of Autophagosome Assembly Regulation Of Transport Negative Regulation Of Metabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Vacuole Organization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Catabolic Process Regulation Of Autophagy TOR Signaling Cytoplasm Focal Adhesion Negative Regulation Of TOR Signaling Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of TORC1 Signaling Regulation Of Cellular Localization Protein Kinase C Inhibitor Activity Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Protein Localization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of TOR Signaling Protein Ubiquitination Phosphoserine Residue Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Modification By Small Protein Conjugation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Macroautophagy Postsynaptic Endocytic Zone Signal Transduction Positive Regulation Of Growth Hormone Secretion Protein-containing Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Monoubiquitinated Protein Deubiquitination Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Postsynaptic Actin Cytoskeleton Phosphorylation-dependent Protein Binding Protein Stabilization
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