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HSPA5 and VWF
Number of citations of the paper that reports this interaction (PubMedID
10887119
)
0
Data Source:
HPRD
(in vivo)
HSPA5
VWF
Description
heat shock protein family A (Hsp70) member 5
von Willebrand factor
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Extracellular Region
Extracellular Space
Endoplasmic Reticulum
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Weibel-Palade Body
Extracellular Exosome
Cell Periphery
Molecular Function
Nucleotide Binding
Calcium Ion Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
Protein Domain Specific Binding
Protein Serine/threonine Kinase Inhibitor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
ATP-dependent Protein Folding Chaperone
Protease Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Immunoglobulin Binding
Identical Protein Binding
Protein-folding Chaperone Binding
Biological Process
Translational Initiation
Protein Folding
ER Overload Response
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Post-translational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Maintenance Of Protein Localization In Endoplasmic Reticulum
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ERAD Pathway
Protein Refolding
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Interleukin-4
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Cell Adhesion
Blood Coagulation
Hemostasis
Response To Wounding
Platelet Activation
Cell-substrate Adhesion
Positive Regulation Of Intracellular Signal Transduction
Pathways
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
ATF6B (ATF6-beta) activates chaperones
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Modulation of host responses by IFN-stimulated genes
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
GP1b-IX-V activation signalling
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Defective F8 cleavage by thrombin
Defective F8 binding to von Willebrand factor
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Antihemophilic factor, human recombinant
Egaptivon pegol
Caplacizumab
Simoctocog alfa
Antihemophilic factor (recombinant), PEGylated
Susoctocog alfa
Efmoroctocog alfa
Lonoctocog alfa
Moroctocog alfa
Turoctocog alfa pegol
Rurioctocog alfa pegol
Diseases
Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS
Refractive error (
32231278
)
Smoking initiation (
33082346
)
Coagulation factor levels (
23267103
)
Factor VIII levels (
20231535
30586737
)
Low vWF levels (
26486471
)
Mean platelet volume (
22139419
27863252
32888494
)
Peginterferon alfa-2a treatment response in chronic hepatitis B infection (
30972912
)
Platelet count (
22139419
26805783
32888494
)
Response to tofacitinib treatment in psoriasis (herpes zoster) (
33455090
)
Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) (
33455090
)
Venous thromboembolism (
31420334
)
vWF levels (
20231535
30586737
)
vWF levels in ischaemic stroke and hyperhomocysteinaemia (
28495826
)
Interacting Genes
77 interacting genes:
A2M
AGO4
APC
APOB
BAG3
BCAR1
CASP7
CDK7
CPT1A
DDX24
DNAJC1
DNAJC10
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
FNDC3B
GRIA1
HLA-C
HMGB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
NEDD4L
NRIP1
OTUD3
PARK7
PAWR
PCSK7
PRDM14
PRNP
PSME3
PTPN11
PTPRF
RIPK4
RNF114
RNF26
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
XAF1
YWHAB
28 interacting genes:
ADAMTS13
ALB
APOA1
ATXN7
CACNA1A
CALR
COL1A1
COL1A2
COL3A1
F8
FGA
FGB
FGG
FURIN
FXR1
GP1BA
HOXA1
HSPA5
ITGA2B
LCOR
MAP3K3
NUFIP2
P4HB
PROS1
RAC1
SOCS4
TNFRSF11B
ZNF512B
Entrez ID
3309
7450
HPRD ID
00682
01906
Ensembl ID
ENSG00000044574
ENSG00000110799
Uniprot IDs
P11021
V9HWB4
P04275
PDB IDs
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
6ZMD
7N1R
1AO3
1ATZ
1AUQ
1FE8
1FNS
1IJB
1IJK
1M10
1OAK
1SQ0
1U0N
1UEX
2ADF
2MHP
2MHQ
3GXB
3HXO
3HXQ
3PPV
3PPW
3PPX
3PPY
3ZQK
4C29
4C2A
4C2B
4DMU
4NT5
5BV8
6FWN
6N29
7EOW
7F49
7KWO
7P4N
7PMV
7PNF
7ZWH
8D3C
8D3D
Enriched GO Terms of Interacting Partners
?
Macromolecule Catabolic Process
Regulation Of Protein Localization
Endoplasmic Reticulum
Protein Metabolic Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Catabolic Process
Catabolic Process
Protein-folding Chaperone Binding
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Autophagy
Negative Regulation Of Establishment Of Protein Localization
Adenyl-nucleotide Exchange Factor Activity
Cotranslational Protein Targeting To Membrane
Molecular Sequestering Activity
Proteolysis
Protein Modification Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Melatonin Receptor Activity
Regulation Of Metabolic Process
Negative Regulation Of Transport
Response To Stress
Regulation Of Protein Transport
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Signal Transduction
Signal Transduction
Immunoglobulin Binding
Cupric Ion Binding
Negative Regulation Of Protein Transport
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Leukocyte Activation
Scaffold Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Proteolysis
Protein Folding
Positive Regulation Of Transcription By RNA Polymerase I
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Cholesterol Storage
Negative Regulation Of T Cell Activation
Ubiquitin-like Protein Conjugating Enzyme Binding
Endoplasmic Reticulum Lumen
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Substrate Adhesion-dependent Cell Spreading
Fibrinolysis
Protein Activation Cascade
Cell-matrix Adhesion
Coagulation
Blood Coagulation
Hemostasis
Platelet Alpha Granule Lumen
Blood Microparticle
Platelet Activation
Positive Regulation Of Cell-substrate Adhesion
Protein Maturation
Regulation Of Cell-substrate Adhesion
Cell-substrate Adhesion
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Extracellular Space
Negative Regulation Of Coagulation
Extracellular Matrix Structural Constituent
Positive Regulation Of Rho Protein Signal Transduction
Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Regulation Of Hemostasis
Fibrinogen Complex
Extracellular Region
Extracellular Matrix
Fibrillar Collagen Trimer
Regulation Of Body Fluid Levels
Blood Coagulation, Fibrin Clot Formation
Zymogen Activation
Protein Processing
Regulation Of Biological Quality
Platelet-derived Growth Factor Binding
Plasminogen Activation
Cell Surface
Regulation Of Signal Transduction
Regulation Of Signaling
Protein Folding In Endoplasmic Reticulum
Regulation Of Cell Communication
Positive Regulation Of Heterotypic Cell-cell Adhesion
External Side Of Plasma Membrane
Negative Regulation Of Multicellular Organismal Process
Extracellular Exosome
Collagen Type I Trimer
Extracellular Matrix Organization
Regulation Of Wound Healing
Extracellular Structure Organization
Platelet Alpha Granule
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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