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HSPA5 and KRT14
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
HSPA5
KRT14
Description
heat shock protein family A (Hsp70) member 5
keratin 14
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Cornified Envelope
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Intermediate Filament
Keratin Filament
Basal Part Of Cell
Extracellular Exosome
Cell Periphery
Molecular Function
Nucleotide Binding
Calcium Ion Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
Protein Domain Specific Binding
Protein Serine/threonine Kinase Inhibitor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
ATP-dependent Protein Folding Chaperone
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Structural Constituent Of Skin Epidermis
Keratin Filament Binding
Biological Process
Translational Initiation
Protein Folding
ER Overload Response
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Post-translational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Maintenance Of Protein Localization In Endoplasmic Reticulum
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ERAD Pathway
Protein Refolding
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Interleukin-4
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Morphogenesis Of An Epithelium
Epidermis Development
Response To Radiation
Keratinocyte Differentiation
Hair Cycle
Intermediate Filament Organization
Intermediate Filament Bundle Assembly
Stem Cell Differentiation
Pathways
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
ATF6B (ATF6-beta) activates chaperones
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Modulation of host responses by IFN-stimulated genes
Type I hemidesmosome assembly
Keratinization
Formation of the cornified envelope
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Zinc
Zinc acetate
Diseases
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
Dermatopathia pigmentosa reticularis
Naegeli-Franceschetti-Jadassohn syndrome
GWAS
Refractive error (
32231278
)
Smoking initiation (
33082346
)
Interacting Genes
77 interacting genes:
A2M
AGO4
APC
APOB
BAG3
BCAR1
CASP7
CDK7
CPT1A
DDX24
DNAJC1
DNAJC10
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
FNDC3B
GRIA1
HLA-C
HMGB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
NEDD4L
NRIP1
OTUD3
PARK7
PAWR
PCSK7
PRDM14
PRNP
PSME3
PTPN11
PTPRF
RIPK4
RNF114
RNF26
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
XAF1
YWHAB
35 interacting genes:
ABI2
ABI3
AMOT
APC
BFSP2
CTTNBP2
DRC4
DST
ENKD1
HGS
HSPA5
KIFC3
KRT1
KRT3
KRT4
KRT5
KRT6C
KRT72
KRT77
KRT78
KRT79
KRT80
KRT81
KRT85
KRT86
OIP5
PKP1
PRPH
PUS10
SDCBP
SMARCE1
TCHP
TRADD
UBASH3A
USHBP1
Entrez ID
3309
3861
HPRD ID
00682
01017
Ensembl ID
ENSG00000044574
ENSG00000186847
Uniprot IDs
P11021
V9HWB4
P02533
PDB IDs
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
6ZMD
7N1R
3TNU
6JFV
Enriched GO Terms of Interacting Partners
?
Macromolecule Catabolic Process
Regulation Of Protein Localization
Endoplasmic Reticulum
Protein Metabolic Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Catabolic Process
Catabolic Process
Protein-folding Chaperone Binding
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Autophagy
Negative Regulation Of Establishment Of Protein Localization
Adenyl-nucleotide Exchange Factor Activity
Cotranslational Protein Targeting To Membrane
Molecular Sequestering Activity
Proteolysis
Protein Modification Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Melatonin Receptor Activity
Regulation Of Metabolic Process
Negative Regulation Of Transport
Response To Stress
Regulation Of Protein Transport
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Signal Transduction
Signal Transduction
Immunoglobulin Binding
Cupric Ion Binding
Negative Regulation Of Protein Transport
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Leukocyte Activation
Scaffold Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Proteolysis
Protein Folding
Positive Regulation Of Transcription By RNA Polymerase I
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Cholesterol Storage
Negative Regulation Of T Cell Activation
Ubiquitin-like Protein Conjugating Enzyme Binding
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Intermediate Filament
Keratin Filament
Keratinization
Cytoskeleton Organization
Supramolecular Fiber Organization
Organelle Organization
Anchoring Junction
Cytosol
Cytoskeleton
Extracellular Exosome
Desmosome
Cell-cell Junction Organization
Cell Junction Organization
Adherens Junction
Polymeric Cytoskeletal Fiber
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Cell-cell Junction Assembly
Actin-based Cell Projection
Intermediate Filament Cytoskeleton
Microtubule Binding
Microtubule Cytoskeleton
Cell Junction Assembly
Cornified Envelope
Protein Binding
SCAR Complex
Positive Regulation Of Exosomal Secretion
Regulation Of Modification Of Postsynaptic Structure
Structural Molecule Activity
Signaling Adaptor Activity
Lamellipodium
Microtubule
Regulation Of Exosomal Secretion
Regulation Of Modification Of Synaptic Structure
Microtubule Plus-end Binding
Cell-cell Junction Maintenance
Cytoskeletal Anchor Activity
Structural Constituent Of Cytoskeleton
Regulation Of Cell Projection Assembly
Regulation Of Protein Folding In Endoplasmic Reticulum
Intermediate Filament Polymerization
Interleukin-5 Receptor Complex
COP9 Signalosome
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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