HSPA5 and PAWR

Number of citations of the paper that reports this interaction (PubMedID 19632185)
24

Data Source:
HPRD (in vitro, in vivo)

		HSPA5	PAWR
Description		heat shock protein family A (Hsp70) member 5	pro-apoptotic WT1 regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Chromatin Nucleus Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Serine/threonine Kinase Inhibitor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Translational Initiation Protein Folding ER Overload Response Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Maintenance Of Protein Localization In Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ERAD Pathway Protein Refolding Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-4 Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways		Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6B (ATF6-beta) activates chaperones Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC Modulation of host responses by IFN-stimulated genes
Drugs		Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation ( 33082346)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		77 interacting genes: A2M AGO4 APC APOB BAG3 BCAR1 CASP7 CDK7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 FNDC3B GRIA1 HLA-C HMGB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 NEDD4L NRIP1 OTUD3 PARK7 PAWR PCSK7 PRDM14 PRNP PSME3 PTPN11 PTPRF RIPK4 RNF114 RNF26 RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF XAF1 YWHAB	14 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SQSTM1 TFPT THAP1 WT1
Entrez ID		3309	5074
HPRD ID		00682	09051
Ensembl ID		ENSG00000044574	ENSG00000177425
Uniprot IDs		P11021 V9HWB4	Q96IZ0
PDB IDs		3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS 6ZMD 7N1R	2JK9
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Regulation Of Protein Localization Endoplasmic Reticulum Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Catabolic Process Protein-folding Chaperone Binding Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Negative Regulation Of Establishment Of Protein Localization Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Molecular Sequestering Activity Proteolysis Protein Modification Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Melatonin Receptor Activity Regulation Of Metabolic Process Negative Regulation Of Transport Response To Stress Regulation Of Protein Transport Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Signal Transduction Signal Transduction Immunoglobulin Binding Cupric Ion Binding Negative Regulation Of Protein Transport Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Leukocyte Activation Scaffold Protein Binding Regulation Of Type I Interferon Production Regulation Of Proteolysis Protein Folding Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of T Cell Proliferation Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Activation Ubiquitin-like Protein Conjugating Enzyme Binding	PML Body Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leucine Zipper Domain Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Morphogenesis Of A Branching Structure Ionotropic Glutamate Receptor Binding Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of RNA Metabolic Process Temperature Homeostasis Negative Regulation Of Translation Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Programmed Cell Death Maintenance Of Protein Localization In Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Choline:sodium Symporter Activity Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Cell Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of DNA-templated Transcription Protein Catabolic Process Cerebellum Structural Organization Maintenance Of Protein Location Maintenance Of Location In Cell Positive Regulation Of Telomere Maintenance Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development
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