HSPA5 and PAWR

Number of citations of the paper that reports this interaction (PMID 19632185)
38

Data Source:
HPRD (in vivo, in vitro)

		HSPA5	PAWR
Gene Name		heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	PRKC, apoptosis, WT1, regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway
Pathways		Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs		Antihemophilic Factor
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB	17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		3309	5074
HPRD ID		00682	09051
Ensembl ID		ENSG00000044574
Uniprot IDs		P11021	Q96IZ0
PDB IDs		3IUC 3LDL 3LDN 3LDO 3LDP	2JK9
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis	Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress
Tagcloud ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Difference) ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Intersection) ?