Wiki-Pi
About
Search
People
Updates
Search
HSPA5 and APC
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
36
Data Source:
BioGRID
(two hybrid)
HSPA5
APC
Description
heat shock protein family A (Hsp70) member 5
APC regulator of Wnt signaling pathway
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Leading Edge Membrane
Ruffle Membrane
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Plasma Membrane Bounded Cell Projection
Wnt Signalosome
Molecular Function
Nucleotide Binding
Calcium Ion Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
Protein Domain Specific Binding
Protein Serine/threonine Kinase Inhibitor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
ATP-dependent Protein Folding Chaperone
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Translational Initiation
Protein Folding
ER Overload Response
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Post-translational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Maintenance Of Protein Localization In Endoplasmic Reticulum
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ERAD Pathway
Protein Refolding
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Interleukin-4
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Mitotic Cytokinesis
Cell Fate Specification
Heart Valve Development
Endocardial Cushion Morphogenesis
DNA Damage Response
Negative Regulation Of Microtubule Depolymerization
Mitotic Spindle Assembly Checkpoint Signaling
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Wnt Signaling Pathway
Cell Migration
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Microtubule-based Movement
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Localization To Centrosome
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
ATF6B (ATF6-beta) activates chaperones
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Modulation of host responses by IFN-stimulated genes
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
Cancer of the anal canal
Familial adenomatous polyposis
Gastric cancer
Esophageal cancer
Gallbladder cancer
GWAS
Refractive error (
32231278
)
Smoking initiation (
33082346
)
Age at first sexual intercourse (
34211149
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Appendicular lean mass (
33097823
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Daytime nap (
33568662
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
77 interacting genes:
A2M
AGO4
APC
APOB
BAG3
BCAR1
CASP7
CDK7
CPT1A
DDX24
DNAJC1
DNAJC10
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
FNDC3B
GRIA1
HLA-C
HMGB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
NEDD4L
NRIP1
OTUD3
PARK7
PAWR
PCSK7
PRDM14
PRNP
PSME3
PTPN11
PTPRF
RIPK4
RNF114
RNF26
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
XAF1
YWHAB
135 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
ATOSA
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG1
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PKNOX1
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
ZNF106
ZNF510
Entrez ID
3309
324
HPRD ID
00682
01439
Ensembl ID
ENSG00000044574
ENSG00000134982
Uniprot IDs
P11021
V9HWB4
P25054
R4GMU6
PDB IDs
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
6ZMD
7N1R
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
7F6M
7F7O
7XTY
8GSJ
8X2Q
Enriched GO Terms of Interacting Partners
?
Macromolecule Catabolic Process
Regulation Of Protein Localization
Endoplasmic Reticulum
Protein Metabolic Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Catabolic Process
Catabolic Process
Protein-folding Chaperone Binding
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Autophagy
Negative Regulation Of Establishment Of Protein Localization
Adenyl-nucleotide Exchange Factor Activity
Cotranslational Protein Targeting To Membrane
Molecular Sequestering Activity
Proteolysis
Protein Modification Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Melatonin Receptor Activity
Regulation Of Metabolic Process
Negative Regulation Of Transport
Response To Stress
Regulation Of Protein Transport
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Signal Transduction
Signal Transduction
Immunoglobulin Binding
Cupric Ion Binding
Negative Regulation Of Protein Transport
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Leukocyte Activation
Scaffold Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Proteolysis
Protein Folding
Positive Regulation Of Transcription By RNA Polymerase I
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Cholesterol Storage
Negative Regulation Of T Cell Activation
Ubiquitin-like Protein Conjugating Enzyme Binding
Organelle Organization
Structural Constituent Of Nuclear Pore
Cytoskeleton Organization
Supramolecular Fiber Organization
Cytosol
MRNA Transport
Nuclear Export
Nuclear Pore
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Beta-catenin Destruction Complex
Nuclear Transport
Nucleocytoplasmic Transport
RNA Transport
Nuclear Membrane
RNA Export From Nucleus
Cellular Localization
Cytoskeleton
Intracellular Protein Localization
Regulation Of Nucleocytoplasmic Transport
Intracellular Transport
Nucleobase-containing Compound Transport
Nuclear Localization Sequence Binding
Nuclear Envelope
Establishment Of Localization In Cell
Cadherin Binding
Regulation Of Protein Localization
Actin Filament Binding
Glutamatergic Synapse
Regulation Of Cellular Localization
Protein Export From Nucleus
Hemidesmosome
Intracellular Protein Transport
Actin Binding
Nucleus
Protein Transport
Cellular Component Assembly
Positive Regulation Of Nucleocytoplasmic Transport
Establishment Of Protein Localization
Cytoplasm
Regulation Of Cytoskeleton Organization
Canonical Wnt Signaling Pathway
Regulation Of Intracellular Transport
Structural Molecule Activity
Intermediate Filament Organization
Nuclear Pore Nuclear Basket
Regulation Of Intracellular Protein Transport
Nuclear Pore Organization
Microtubule
Regulation Of Centromeric Sister Chromatid Cohesion
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?