HSPA5 and APOB

Number of citations of the paper that reports this interaction (PMID 12397072)
19

Data Source:
HPRD (in vitro, in vivo)

		HSPA5	APOB
Gene Name		heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	apolipoprotein B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Actin Cytoskeleton Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding	Protein Binding Phospholipid Binding Heparin Binding Cholesterol Transporter Activity Lipase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport	Retinoid Metabolic Process In Utero Embryonic Development Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Sperm Motility Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Small Molecule Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Transmembrane Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus
Pathways		Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System	Lipoprotein metabolism LDL-mediated lipid transport Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Cell surface interactions at the vascular wall Platelet homeostasis Visual phototransduction Scavenging by Class H Receptors Platelet sensitization by LDL Scavenging by Class F Receptors Scavenging by Class A Receptors Scavenging by Class B Receptors Orphan transporters Retinoid metabolism and transport
Drugs		Antihemophilic Factor
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol ( 20864672 19060911 20686565) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 21059979 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Response to statin therapy ( 20339536) Triglycerides ( 18193044 20864672 19060906 19060911 17463246 20686565)
Protein-Protein Interactions		53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB	22 interactors: AKT2 APOA1 ARFGAP1 BGN CALR CANX HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3
Entrez ID		3309	338
HPRD ID		00682	00133
Ensembl ID		ENSG00000044574	ENSG00000084674
Uniprot IDs		P11021	P04114 Q59HB3 Q7Z7Q0
PDB IDs		3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis	Protein Folding Response To Unfolded Protein Receptor-mediated Endocytosis Protein Metabolic Process Chaperone-mediated Protein Folding Transport Cellular Protein Metabolic Process Vesicle-mediated Transport Protein Stabilization Plasma Lipoprotein Particle Clearance Endocytosis Regulation Of Protein Stability Protein Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Establishment Of Protein Localization Protein Localization Regulation Of Plasma Lipoprotein Particle Levels Response To Endoplasmic Reticulum Stress Establishment Of Localization In Cell Cholesterol Transport Sterol Transport Protein Refolding Cholesterol Homeostasis Sterol Homeostasis Endoplasmic Reticulum Unfolded Protein Response Homeostatic Process Cellular Response To Unfolded Protein Cholesterol Import Cellular Localization Regulation Of Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression ER-nucleus Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Cellular Response To Topologically Incorrect Protein Response To Abiotic Stimulus Cellular Metabolic Process Lipid Homeostasis Cellular Response To Stress Response To Organic Substance Sequestering Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Secretion By Cell Lipid Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Chemical Homeostasis Lipid Localization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Phosphorylation
Tagcloud ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Difference) ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Intersection) ?