PGRMC1 and ZNF71

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC1	ZNF71
Description		progesterone receptor membrane component 1	zinc finger protein 71
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse	Nucleus
	Molecular Function	Amyloid-beta Binding Steroid Binding Protein Binding Lipid Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Heme Biosynthetic Process Axon Guidance Memory Associative Learning Modification Of Synaptic Structure Positive Regulation Of Lipoprotein Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Synapse Organization	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neutrophil degranulation	Generic Transcription Pathway
Drugs		Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS		Hodgkin's lymphoma ( 34216518)	IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 LINC00632 MTNR1A PAM16 SCAP SGTB TMEM213 ZNF71	26 interacting genes: BYSL CSNK2B DVL3 FXR1 KDM1A LGALS14 MFAP1 PGRMC1 PHF1 PICK1 PLK1 PRKCZ PRPF31 RIN3 SART3 SSX2IP TRIM41 U2AF2 ZBTB9 ZGPAT ZNF417 ZNF497 ZNF524 ZNF648 ZNF792 ZNF835
Entrez ID		10857	58491
HPRD ID		02338	11838
Ensembl ID		ENSG00000101856	ENSG00000197951
Uniprot IDs		O00264 Q6IB11	M0R0C0 Q9NQZ8
PDB IDs		4X8Y
Enriched GO Terms of Interacting Partners?		GET Complex	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Zinc Ion Binding U4 SnRNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Biosynthetic Process Spliceosomal Tri-snRNP Complex Assembly Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Component Organization DNA Repair-dependent Chromatin Remodeling Identical Protein Binding U2-type Spliceosomal Complex
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