PGRMC1 and DEFB124

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC1	DEFB124
Description		progesterone receptor membrane component 1	defensin beta 124
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse	Extracellular Region
	Molecular Function	Amyloid-beta Binding Steroid Binding Protein Binding Lipid Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding
	Biological Process	Heme Biosynthetic Process Axon Guidance Memory Associative Learning Modification Of Synaptic Structure Positive Regulation Of Lipoprotein Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Synapse Organization	Defense Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Defense Response To Bacterium Innate Immune Response Cellular Response To Peptidoglycan Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Neutrophil degranulation	Beta defensins Defensins
Drugs		Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS		Hodgkin's lymphoma ( 34216518)
Interacting Genes		20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 LINC00632 MTNR1A PAM16 SCAP SGTB TMEM213 ZNF71	2 interacting genes: NCK2 PGRMC1
Entrez ID		10857	245937
HPRD ID		02338	18759
Ensembl ID		ENSG00000101856	ENSG00000180383
Uniprot IDs		O00264 Q6IB11	Q8NES8
PDB IDs		4X8Y
Enriched GO Terms of Interacting Partners?		GET Complex	Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cytoskeletal Anchor Activity Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Immunological Synapse Formation Negative Regulation Of PERK-mediated Unfolded Protein Response Dendritic Spine Development Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Lipoprotein Transport Negative Regulation Of Synapse Organization Smooth Endoplasmic Reticulum Membrane Heme Biosynthetic Process Modification Of Synaptic Structure Synapse Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Steroid Binding Signaling Receptor Complex Adaptor Activity Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cell Projection Organization Vesicle Membrane Heme Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Porphyrin-containing Compound Metabolic Process Lamellipodium Organization Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Tetrapyrrole Metabolic Process Cell-cell Recognition Pigment Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Scaffold Protein Binding ERBB Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Protein Localization To Cell Periphery
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