PGRMC1 and TMEM213

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGRMC1	TMEM213
Description		progesterone receptor membrane component 1	transmembrane protein 213
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse	Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Amyloid-beta Binding Steroid Binding Protein Binding Lipid Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Heme Biosynthetic Process Axon Guidance Memory Associative Learning Modification Of Synaptic Structure Positive Regulation Of Lipoprotein Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Synapse Organization
Pathways		Neutrophil degranulation
Drugs		Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS		Hodgkin's lymphoma ( 34216518)
Interacting Genes		20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 LINC00632 MTNR1A PAM16 SCAP SGTB TMEM213 ZNF71	4 interacting genes: MAL MAT2A PGRMC1 TCF4
Entrez ID		10857	155006
HPRD ID		02338	19298
Ensembl ID		ENSG00000101856	ENSG00000214128
Uniprot IDs		O00264 Q6IB11	A2RRL7
PDB IDs		4X8Y
Enriched GO Terms of Interacting Partners?		GET Complex	Protein Localization To Paranode Region Of Axon Protein Insertion Into Plasma Membrane Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Methionine Adenosyltransferase Activity Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Peptidase Activator Activity Involved In Apoptotic Process Positive Regulation Of Lipoprotein Transport Cellular Response To Methionine Membrane Raft Distribution Response To Methionine Membrane Raft Localization Smooth Endoplasmic Reticulum Membrane Protein Localization To Axon Lipid Binding Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath S-adenosylmethionine Metabolic Process Protein Hexamerization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Beta-catenin-TCF Complex Apical Protein Localization Negative Regulation Of Synapse Organization One-carbon Metabolic Process Heme Biosynthetic Process Modification Of Synaptic Structure Small Molecule Binding Membrane Raft Organization Protein Heterooligomerization Tetrapyrrole Biosynthetic Process Steroid Binding Porphyrin-containing Compound Biosynthetic Process
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