MAP3K3 and YWHAQ

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro)

		MAP3K3	YWHAQ
Gene Name		mitogen-activated protein kinase kinase kinase 3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
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Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Height ( 21998595 22021425 18391951)	Heart rate variability traits ( 22174390)
Protein-Protein Interactions		44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2
Entrez ID		4215	10971
HPRD ID		03965	00886
Ensembl ID		ENSG00000198909	ENSG00000134308
Uniprot IDs		J3KRN4 J3QRB6 Q99759	B4DMT8 P27348
PDB IDs		2C60 2JRH 2O2V 2PPH	2BTP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity
Tagcloud ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a
Tagcloud (Difference) ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a
Tagcloud (Intersection) ?