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MAP3K3 and MAP3K7
Number of citations of the paper that reports this interaction (PubMedID
16260783
)
0
Data Source:
HPRD
(two hybrid, in vivo)
MAP3K3
MAP3K7
Description
mitogen-activated protein kinase kinase kinase 3
mitogen-activated protein kinase kinase kinase 7
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
ATAC Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Kinase Activity
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Kinase Activity
Identical Protein Binding
Metal Ion Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Linear Polyubiquitin Binding
Biological Process
MAPK Cascade
Blood Vessel Development
Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Autophosphorylation
Positive Regulation Of P38MAPK Cascade
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Chromatin Remodeling
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Metabolic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Signal Transduction Involved In Regulation Of Gene Expression
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon Production
Protein Exit From Endoplasmic Reticulum
Positive Regulation Of Interleukin-2 Production
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
P38MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
Defense Response To Bacterium
Signal Transduction In Response To DNA Damage
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Cellular Response To Angiotensin
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Response To Angiotensin
Pathways
Interleukin-1 signaling
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Height (
18391951
21998595
22021425
25429064
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Waist circumference adjusted for body mass index (
34021172
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Interacting Genes
44 interacting genes:
BIRC2
BRCA1
CDC37
COPS5
EGFR
GAB1
GLRX3
GTF2I
HSP90AA1
HSP90AB1
HSPA2
IKBKB
LATS1
MAP2K3
MAP2K4
MAP2K5
MAP2K7
MAP3K5
MAP3K7
MARK2
MBP
NEDD4
NEDD4L
NFKBIA
PFDN2
PRKACA
RCAN1
RIPK1
SMURF1
SPAG9
TOM1L1
TRAF6
TRAF7
VWF
WNK1
XIAP
YAP1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZBTB16
73 interacting genes:
AKTIP
BBS10
BCL10
CALML6
CAMK2G
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FOS
GPR25
HGS
HIPK2
IKBKB
IL17RD
IRAK1
MAILR
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
SUPT20H
TAB1
TAB2
TGFBR1
TNFAIP8L2
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
USP29
USP4
USP8
VRK2
XIAP
ZNF593
ZNF746
Entrez ID
4215
6885
HPRD ID
03965
04011
Ensembl ID
ENSG00000198909
ENSG00000135341
Uniprot IDs
J3KRN4
J3QRB6
Q96HN9
Q99759
O43318
PDB IDs
2C60
2JRH
2O2V
2PPH
4Y5O
4YL6
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
7NTH
7NTI
8GW3
9FPD
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Intracellular Signaling Cassette
MAPK Cascade
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Cytosol
Positive Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Identical Protein Binding
Negative Regulation Of Signal Transduction
Cytoplasm
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Developmental Process
Protein Serine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Regulation Of Macromolecule Metabolic Process
Transferase Activity
Protein Domain Specific Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein-containing Complex
Positive Regulation Of Biosynthetic Process
Phosphoserine Residue Binding
Protein Modification Process
Response To Tumor Necrosis Factor
Protein Kinase Binding
Regulation Of Metabolic Process
Kinase Activity
Negative Regulation Of Intracellular Signal Transduction
Enzyme Binding
Fc-epsilon Receptor Signaling Pathway
Ubiquitin Protein Ligase Binding
Regulation Of Apoptotic Process
Stress-activated Protein Kinase Signaling Cascade
Cellular Response To Tumor Necrosis Factor
Cellular Response To Cytokine Stimulus
Intracellular Signaling Cassette
Intracellular Signal Transduction
MAPK Cascade
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Signal Transduction
Innate Immune Response-activating Signaling Pathway
Protein Kinase Activity
Regulation Of Cytokine Production
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Activation Of Innate Immune Response
Protein Modification Process
Regulation Of Defense Response
Negative Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Positive Regulation Of Innate Immune Response
Response To Stress
Regulation Of MAPK Cascade
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Cytoplasm
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Immune Response
Regulation Of DNA-binding Transcription Factor Activity
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of JNK Cascade
Immune Response-regulating Signaling Pathway
Cytosol
Regulation Of Apoptotic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Immune System Process
Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Transferase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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