MAP3K3 and SPAG9

Number of citations of the paper that reports this interaction (PMID 12391307)
21

Data Source:
HPRD (in vitro)

		MAP3K3	SPAG9
Gene Name		mitogen-activated protein kinase kinase kinase 3	sperm associated antigen 9
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Acrosomal Vesicle Cytoplasm Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity Mitogen-activated Protein Kinase P38 Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Activation Of JUN Kinase Activity Spermatogenesis Positive Regulation Of Cell Migration Retrograde Transport, Endosome To Golgi Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Homooligomerization Negative Regulation Of Protein Homodimerization Activity
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Height ( 21998595 22021425 18391951)
Protein-Protein Interactions		44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	11 interactors: KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 TP53BP1
Entrez ID		4215	9043
HPRD ID		03965	10398
Ensembl ID		ENSG00000198909	ENSG00000008294
Uniprot IDs		J3KRN4 J3QRB6 Q99759	O60271 Q5JB53
PDB IDs		2C60 2JRH 2O2V 2PPH	2W83
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Response To Stress Response To Stress Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Innate Immune Response Cellular Response To Mechanical Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Immune Response-regulating Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To External Stimulus Response To Abiotic Stimulus Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Response To Growth Factor Response To Mechanical Stimulus Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Organelle Disassembly Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction
Tagcloud ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	afp antigen behavior bel biomarker colony contributes correlated cyclin depletion downregulated hcc hepatocellular immunohistochemistry interfering knockdown malignant marker mtt multiplicity overexpressed overexpression pattern poor relapse serves sirna sperm transfection
Tagcloud (Difference) ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	afp antigen behavior bel biomarker colony contributes correlated cyclin depletion downregulated hcc hepatocellular immunohistochemistry interfering knockdown malignant marker mtt multiplicity overexpressed overexpression pattern poor relapse serves sirna sperm transfection
Tagcloud (Intersection) ?