MAP3K3 and SPAG9

Number of citations of the paper that reports this interaction (PubMedID 12391307)
32

Data Source:
HPRD (in vitro)

		MAP3K3	SPAG9
Description		mitogen-activated protein kinase kinase kinase 3	sperm associated antigen 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Acrosomal Vesicle Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity Identical Protein Binding
	Biological Process	MAPK Cascade Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	MAPK Cascade Vesicle-mediated Transport Positive Regulation Of Cell Migration Lysosome Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Negative Regulation Of Dendrite Extension
Pathways		Interleukin-1 signaling	Myogenesis Myogenesis
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Height ( 18391951 21998595 22021425 25429064 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Body fat mass ( 28552196) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		44 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YAP1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	13 interacting genes: ARF6 KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 SNCA TP53BP1
Entrez ID		4215	9043
HPRD ID		03965	10398
Ensembl ID		ENSG00000198909	ENSG00000008294
Uniprot IDs		J3KRN4 J3QRB6 Q96HN9 Q99759	O60271 Q5JB53
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6	2W83
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette MAPK Cascade Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Identical Protein Binding Negative Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Developmental Process Protein Serine Kinase Activity Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Macromolecule Metabolic Process Transferase Activity Protein Domain Specific Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Biosynthetic Process Phosphoserine Residue Binding Protein Modification Process Response To Tumor Necrosis Factor Protein Kinase Binding Regulation Of Metabolic Process Kinase Activity Negative Regulation Of Intracellular Signal Transduction Enzyme Binding Fc-epsilon Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus	MAPK Cascade Response To Mechanical Stimulus Myc-Max Complex Response To Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Cellular Senescence JNK Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intracellular Signaling Cassette Cellular Response To Mechanical Stimulus Apoptotic Process Protein-containing Complex Organization Cell Death Programmed Cell Death Cellular Response To Stress Regulation Of Immune System Process MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Response To Growth Factor Protein Serine Kinase Activity Positive Regulation Of Cyclase Activity Intracellular Signal Transduction Regulation Of Presynapse Assembly Cytoplasm Regulation Of Presynapse Organization Response To Muscle Stretch Negative Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Protein Serine/threonine Kinase Activity Stress-activated Protein Kinase Signaling Cascade Protein-containing Complex Disassembly Fc-epsilon Receptor Signaling Pathway Protein Localization To Site Of Double-strand Break Response To UV Response To Radiation Cellular Response To Radiation Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Synaptic Vesicle Endocytosis Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Activity Presynaptic Endocytosis
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