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MAP3K3 and YWHAB
Number of citations of the paper that reports this interaction (PubMedID
14743216
)
0
Data Source:
HPRD
(in vitro)
MAP3K3
YWHAB
Description
mitogen-activated protein kinase kinase kinase 3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Biological Process
MAPK Cascade
Blood Vessel Development
Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Autophosphorylation
Positive Regulation Of P38MAPK Cascade
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Interleukin-1 signaling
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Fostamatinib
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Height (
18391951
21998595
22021425
25429064
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Waist circumference adjusted for body mass index (
34021172
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
44 interacting genes:
BIRC2
BRCA1
CDC37
COPS5
EGFR
GAB1
GLRX3
GTF2I
HSP90AA1
HSP90AB1
HSPA2
IKBKB
LATS1
MAP2K3
MAP2K4
MAP2K5
MAP2K7
MAP3K5
MAP3K7
MARK2
MBP
NEDD4
NEDD4L
NFKBIA
PFDN2
PRKACA
RCAN1
RIPK1
SMURF1
SPAG9
TOM1L1
TRAF6
TRAF7
VWF
WNK1
XIAP
YAP1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZBTB16
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
4215
7529
HPRD ID
03965
03184
Ensembl ID
ENSG00000198909
ENSG00000166913
Uniprot IDs
J3KRN4
J3QRB6
Q96HN9
Q99759
P31946
V9HWD6
PDB IDs
2C60
2JRH
2O2V
2PPH
4Y5O
4YL6
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Intracellular Signaling Cassette
MAPK Cascade
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Cytosol
Positive Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Identical Protein Binding
Negative Regulation Of Signal Transduction
Cytoplasm
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Developmental Process
Protein Serine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Regulation Of Macromolecule Metabolic Process
Transferase Activity
Protein Domain Specific Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein-containing Complex
Positive Regulation Of Biosynthetic Process
Phosphoserine Residue Binding
Protein Modification Process
Response To Tumor Necrosis Factor
Protein Kinase Binding
Regulation Of Metabolic Process
Kinase Activity
Negative Regulation Of Intracellular Signal Transduction
Enzyme Binding
Fc-epsilon Receptor Signaling Pathway
Ubiquitin Protein Ligase Binding
Regulation Of Apoptotic Process
Stress-activated Protein Kinase Signaling Cascade
Cellular Response To Tumor Necrosis Factor
Cellular Response To Cytokine Stimulus
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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