MAP3K3 and RCAN1

Number of citations of the paper that reports this interaction (PMID 16126726)
14

Data Source:
HPRD (in vivo)

		MAP3K3	RCAN1
Gene Name		mitogen-activated protein kinase kinase kinase 3	regulator of calcineurin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Nucleus
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Regulation Of Transcription, DNA-templated Signal Transduction Central Nervous System Development Blood Circulation Calcium-mediated Signaling
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS		Height ( 21998595 22021425 18391951)
Protein-Protein Interactions		44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	7 interactors: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA UXT
Entrez ID		4215	1827
HPRD ID		03965	04226
Ensembl ID		ENSG00000198909	ENSG00000159200
Uniprot IDs		J3KRN4 J3QRB6 Q99759	P53805 Q6FGP2
PDB IDs		2C60 2JRH 2O2V 2PPH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cardiac Muscle Hypertrophy Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Regulation Of Cellular Response To Heat Cellular Protein Modification Process Regulation Of Kinase Activity Regulation Of Binding Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Myotube Differentiation Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Heat Activation Of MAPKK Activity System Development Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Regulation Of Intracellular Transport Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of RNA Metabolic Process Immune Response Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation flna heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Difference) ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation flna heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Intersection) ?