MAP3K3 and RCAN1

Number of citations of the paper that reports this interaction (PubMedID 16126726)
0

Data Source:
HPRD (in vivo)

		MAP3K3	RCAN1
Description		mitogen-activated protein kinase kinase kinase 3	regulator of calcineurin 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleic Acid Binding Protein Phosphatase Inhibitor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Identical Protein Binding
	Biological Process	MAPK Cascade Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Response To Ischemia Response To Stress Response To Oxidative Stress Skeletal Muscle Tissue Development Short-term Memory Response To Mechanical Stimulus Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Estrogen Skeletal Muscle Fiber Development Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Interleukin-1 signaling
Drugs		Fostamatinib	Dipyridamole
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Height ( 18391951 21998595 22021425 25429064 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Cancer ( 29299148) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		44 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YAP1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	22 interacting genes: APP BTRC CXXC5 E2F3 GSK3B MAP3K3 MAPK3 NEUROD2 PICK1 PPP3CA PPP3CB PPP3R1 PRDM4 PTPRD SF3A2 SOX10 SOX9 SPARCL1 USP22 UXT ZNF292 ZNF350
Entrez ID		4215	1827
HPRD ID		03965	04226
Ensembl ID		ENSG00000198909	ENSG00000159200
Uniprot IDs		J3KRN4 J3QRB6 Q96HN9 Q99759	B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6	6UUQ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette MAPK Cascade Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Identical Protein Binding Negative Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Developmental Process Protein Serine Kinase Activity Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Macromolecule Metabolic Process Transferase Activity Protein Domain Specific Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Biosynthetic Process Phosphoserine Residue Binding Protein Modification Process Response To Tumor Necrosis Factor Protein Kinase Binding Regulation Of Metabolic Process Kinase Activity Negative Regulation Of Intracellular Signal Transduction Enzyme Binding Fc-epsilon Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus	Regulation Of Calcium-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Transcription By RNA Polymerase II Glial Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Protein Serine/threonine Phosphatase Complex Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Glutamatergic Synapse Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Signaling Cassette Cell Development Regulation Of Endocytosis Positive Regulation Of Calcium Ion Import Protein Dimerization Activity Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Monoatomic Ion Transport Regulation Of Vesicle-mediated Transport Calmodulin-dependent Protein Phosphatase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport
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