MAP3K3 and WNK1

Number of citations of the paper that reports this interaction (PubMedID 14681216)
0

Data Source:
HPRD (in vitro, in vivo)

		MAP3K3	WNK1
Description		mitogen-activated protein kinase kinase kinase 3	WNK lysine deficient protein kinase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Membrane Protein-containing Complex Intracellular Membraneless Organelle Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Molecular Condensate Scaffold Activity
	Biological Process	MAPK Cascade Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Monoatomic Ion Transport Cell Volume Homeostasis DNA Damage Response Signal Transduction Heart Development Regulation Of Blood Pressure Negative Regulation Of Autophagy Negative Regulation Of Sodium Ion Transport Regulation Of MRNA Export From Nucleus Positive Regulation Of T Cell Chemotaxis Intracellular Chloride Ion Homeostasis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Sodium Ion Transmembrane Transport Chemokine (C-C Motif) Ligand 21 Signaling Pathway Homeostatic Process Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Neuron Development T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Potassium Ion Homeostasis Monoatomic Cation Homeostasis Cellular Hyperosmotic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Membraneless Organelle Assembly Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Termination Of RNA Polymerase II Transcription Cellular Response To Chemokine
Pathways		Interleukin-1 signaling	Stimuli-sensing channels
Drugs		Fostamatinib
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Height ( 18391951 21998595 22021425 25429064 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil count ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		44 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YAP1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 OXSR1 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		4215	65125
HPRD ID		03965	05570
Ensembl ID		ENSG00000198909	ENSG00000060237
Uniprot IDs		J3KRN4 J3QRB6 Q96HN9 Q99759	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6	4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Intracellular Signaling Cassette MAPK Cascade Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Identical Protein Binding Negative Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Developmental Process Protein Serine Kinase Activity Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Macromolecule Metabolic Process Transferase Activity Protein Domain Specific Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Biosynthetic Process Phosphoserine Residue Binding Protein Modification Process Response To Tumor Necrosis Factor Protein Kinase Binding Regulation Of Metabolic Process Kinase Activity Negative Regulation Of Intracellular Signal Transduction Enzyme Binding Fc-epsilon Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus	Cytoplasm Cytosol Focal Adhesion MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Enzyme Binding Response To Temperature Stimulus Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Kinase Activity Intracellular Signal Transduction Establishment Of Localization In Cell Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Phosphoserine Residue Binding Protein Kinase Activity Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Negative Regulation Of Immune System Process Ciliary Base Protein Sequestering Activity Regulation Of CAMP/PKA Signal Transduction Intracellular Transport Protein Autophosphorylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Identical Protein Binding Nuclear Transport Nucleocytoplasmic Transport RNA Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity ERK1 And ERK2 Cascade Regulation Of Membrane Potential Regulation Of TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Protein Kinase Binding TORC1 Signaling
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